A Trial to Learn How Well Linvoseltamab Works Compared to the Combination of Elotuzumab, Pomalidomide and Dexamethasone for Adult Participants With Relapsed/Refractory Multiple Myeloma
- Conditions
- Relapsed Refractory Multiple Myeloma (RRMM)
- Interventions
- Registration Number
- NCT05730036
- Lead Sponsor
- Regeneron Pharmaceuticals
- Brief Summary
This study is researching an experimental drug called linvoseltamab, also called REGN5458.
Linvoseltamab has previously been studied by itself (without other cancer drugs) in participants who had advanced multiple myeloma that returned and needed to be treated again after many other therapies had failed. These participants were no longer benefiting from standard medications and had no good treatment options. In that study, some participants who were treated with linvoseltamab had improvement of their myeloma (shrinkage of their tumors), including some participants who had complete responses (that is, the treatment got rid of all evidence of myeloma in their bodies).
This study is focused on participants who have multiple myeloma that has returned or needs to be treated again after one to four prior treatments and have standard cancer treatment options available to them. The aim of this study is to see how safe and effective linvoseltamab is compared to a combination of three cancer drugs: elotuzumab, pomalidomide and dexamethasone, (called EPd) in participants who have returned after having received prior treatment that included lenalidomide, a proteosome inhibitor, and (for participants in some countries) a cluster of differentiation 38 (CD38) antibody. Half of the participants in this study will get linvoseltamab, and the other half will get EPd.
This study is looking at several other research questions, including:
* How long participants benefit from receiving linvoseltamab compared with EPd
* How many participants treated with linvoseltamab or EPd have improvement of their multiple myeloma and by how much
* What side effects happen from taking linvoseltamab compared to EPd
* How long participants live while receiving treatment or after treatment with linvoseltamab compared to EPd
* If there is any improvement in pain after treatment with linvoseltamab compared to EPd
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 380
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Age 18 years or older (or legal adult age in the country) at the time of the screening visit.
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Eastern Cooperative Oncology Group (ECOG) performance status ≤1. Patients with ECOG 2 solely due to local symptoms of myeloma (eg. pain) may be allowed after discussion with the Medical Monitor.
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Received at least 1 and no more than 4 prior lines of anti-neoplastic MM therapies, including lenalidomide and a proteasome inhibitor and demonstrated disease progression on or after the last therapy as defined by the 2016 IMWG criteria. Participants who have received only 1 line of prior line of antimyeloma therapy must be lenalidomide refractory, as described in the protocol.
Note: Participants in Israel also must have previously received a CD38 antibody. Participants in the EU and the UK must have previously received 2 to 4 prior lines of therapy, including a CD38 antibody.
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Patients must have measurable disease for response assessment as per the 2016 IMWG response assessment criteria, as described in the protocol
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Adequate hematologic function and hepatic function within 7 days of randomization, as well as adequate renal and cardiac function and corrected calcium
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Life expectancy of at least 6 months
Key
- Diagnosis of plasma cell leukemia, amyloidosis, Waldenström macroglobulinemia, or POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes).
- Prior treatment with elotuzumab and/or pomalidomide
- Participants with known MM brain lesions or meningeal involvement
- Treatment with any systemic anti-cancer therapy within 5 half-lives or within 28 days before first administration of study drug, whichever is shorter
- History of allogeneic stem cell transplantation within 6 months, or autologous stem cell transplantation within 12 weeks of the start of study treatment. Participants who have received an allogeneic transplant must be off all immunosuppressive medications for 6 weeks without signs of graft-versus-host disease. Steroids at doses equivalent to suppletion doses may be acceptable.
- Prior treatment with B-cell maturation antigen (BCMA) directed immunotherapies Note: BCMA antibody-drug conjugates are allowed.
- History of progressive multifocal leukoencephalopathy (PML), known or suspected PML, or history of a neurocognitive condition or central nervous system (CNS) movement disorder (Parkinson's disease or Parkinsonism).
- Any infection requiring hospitalization or treatment with IV anti-infectives within 2 weeks of first administration of study drug
- Uncontrolled infection with human immunodeficiency virus (HIV), hepatitis B virus (HBV) or hepatitis C virus (HCV); or another uncontrolled infection, as defined in the protocol 10 Cardiac ejection fraction <40%.
NOTE: Other protocol defined inclusion/exclusion criteria apply
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Linvoseltamab Linvoseltamab Randomization 1:1 Elotuzumab/Pomalidomide/Dexamethasone (EPd) Elotuzumab Randomization 1:1 Elotuzumab/Pomalidomide/Dexamethasone (EPd) Pomalidomide Randomization 1:1 Elotuzumab/Pomalidomide/Dexamethasone (EPd) Dexamethasone Randomization 1:1
- Primary Outcome Measures
Name Time Method Progression Free Survival (PFS) per International Myeloma Working Group (IMWG) response criteria determined by Independent Review Committee (IRC) in CD38 antibody exposed participants Up to approximatively 5 years
- Secondary Outcome Measures
Name Time Method OS in all participants Up to approximatively 5 years Incidence of minimal residual disease (MRD) negative status in participants previously exposed to CD38 antibodies Up to approximatively 5 years Incidence of MRD negative status in all participants Up to approximatively 5 years DoR as per IMWG response criteria as determined by the IRC in all participants Up to approximatively 5 years Objective Response (OR) of Complete Response (CR) or better per IMWG response criteria as determined by IRC in CD38 antibody exposed participants Up to approximatively 5 years OR of CR or better per IMWG response criteria as determined by IRC in all participants Up to approximatively 5 years Overall Survival (OS) in participants previously exposed to CD38 antibodies Up to approximatively 5 years PFS per IMWG response criteria determined by IRC in all participants Up to approximatively 5 years Mean change in the worst pain score measured by Brief Pain Inventory-Short Form (BPI-SF) Item 3 in participants previously exposed to CD38 antibodies Baseline to week 12 The BPI-SF is a validated, self-administered questionnaire designed to measure a participant's perceived level of pain. The BPI-SF Item 3 uses a numeric rating scale to assess pain severity and pain interference in the past 24 hours. The numeric rating scale ranges from 0 (no pain) to 10 (worst imaginable pain), where higher scores indicate greater intensity of pain.
Mean change in the worst pain score measured by BPI-SF Item 3 in all participants Baseline to week 12 The BPI-SF is a validated, self-administered questionnaire designed to measure a participant's perceived level of pain. The BPI-SF Item 3 uses a numeric rating scale to assess pain severity and pain interference in the past 24 hours. The numeric rating scale ranges from 0 (no pain) to 10 (worst imaginable pain), where higher scores indicate greater intensity of pain.
Incidence of treatment emergent adverse events (TEAEs) in participants previously exposed to CD38 antibodies Up to approximatively 5 years Incidence TEAEs in all participants Up to approximatively 5 years Severity of TEAEs in participants previously exposed to CD38 antibodies Up to approximatively 5 years Severity of TEAEs in all participants Up to approximatively 5 years Incidence of adverse events of special interest (AESI) in participants previously exposed to CD38 antibodies Up to approximatively 5 years Incidence of AESI in all participants Up to approximatively 5 years Severity of AESI in participants previously exposed to CD38 antibodies Up to approximatively 5 years Severity AESI in all participants Up to approximatively 5 years Incidence of Serious Adverse Events (SAE) in participants previously exposed to CD38 antibodies Up to approximatively 5 years Incidence of SAE in all participants Up to approximatively 5 years Severity of SAE in participants previously exposed to CD38 antibodies Up to approximatively 5 years Severity of SAE in all participants Up to approximatively 5 years PFS per IMWG response criteria as determined by the investigator in participants previously exposed to CD38 antibodies Up to approximatively 5 years PFS per IMWG response criteria as determined by the investigator in all participants Up to approximatively 5 years OR of Partial Response (PR) or better per IMWG response criteria as determined by the IRC in CD38 antibody exposed participants Up to approximatively 5 years OR of PR or better per IMWG response criteria as determined by the IRC in all participants Up to approximatively 5 years OR of Very Good Partial Response (VGPR) or better per IMWG response criteria as determined by IRC in CD38 antibody exposed participants Up to approximatively 5 years OR of VGPR or better per IMWG response criteria as determined by IRC in all participants Up to approximatively 5 years OR of PR or better per IMWG response criteria as determined by the investigator in participants previously exposed to CD38 antibodies Up to approximatively 5 years OR of PR or better per IMWG response criteria as determined by the investigator in all participants Up to approximatively 5 years OR of VGPR or better per IMWG response criteria as determined by the investigator in participants previously exposed to CD38 antibodies Up to approximatively 5 years OR of VGPR or better per IMWG response criteria as determined by the investigator in all participants Up to approximatively 5 years OR of CR or better per IMWG response criteria as determined by the investigator in participants previously exposed to CD38 antibodies Up to approximatively 5 years OR of CR or better per IMWG response criteria as determined by the investigator in all participants Up to approximatively 5 years Duration of Response (DoR) as per IMWG response criteria as determined by the investigator in participants previously exposed to CD38 antibodies Up to approximatively 5 years DoR as per IMWG response criteria as determined by the investigator in all participants Up to approximatively 5 years DoR as per IMWG response criteria as determined by the IRC in participants previously exposed to CD38 antibodies Up to approximatively 5 years Duration of MRD negative status in the bone marrow in participants previously exposed to CD38 antibodies Up to approximatively 5 years Duration of MRD negative status in the bone marrow in all participants Up to approximatively 5 years Time from randomization to objective response (≥PR) as per IMWG response criteria as determined by the investigator in participants previously exposed to CD38 antibodies Up to approximatively 5 years Time from randomization to objective response (≥PR) as per IMWG response criteria as determined by the investigator in all participants Up to approximatively 5 years Time from randomization to objective response (≥PR) as per IMWG response criteria as determined by the IRC in participants previously exposed to CD38 antibodies Up to approximatively 5 years Time from randomization to objective response (≥PR) as per IMWG response criteria as determined by the IRC in all participants Up to approximatively 5 years Concentration of linvoseltamab in the serum over time in participants previously exposed to CD38 antibodies Up to approximatively 5 years Concentration of linvoseltamab in the serum over time in all participants Up to approximatively 5 years Incidence of antidrug antibodies (ADAs) in participants previously exposed to CD38 antibodies Up to approximatively 5 years Incidence of ADAs in all participants Up to approximatively 5 years Titer of ADAs in participants previously exposed to CD38 antibodies Up to approximatively 5 years Titer of ADAs in all participants Up to approximatively 5 years Incidence of neutralizing antibodies (Nabs) to linvoseltamab over time in participants previously exposed to CD38 antibodies Up to approximatively 5 years Incidence of Nabs to linvoseltamab over time in all participants Up to approximatively 5 years Proportion of Pain Responders in participants previously exposed to CD38 antibodies At week 12 Defined by at least a 2-point reduction from baseline in the BPI-SF Item 3 without an increase in analgesic use using the modified Analgesic Quantification Algorithm (AQA).
Proportion of Pain Responders in all participants At week 12 Defined by at least a 2-point reduction from baseline in the BPI-SF Item 3 without an increase in analgesic use using the modified Analgesic Quantification Algorithm (AQA).
Change in patient-reported global health status/quality of life (QoL), per European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) in participants previously exposed to CD38 antibodies Baseline to week 12 The EORTC-QLQ-C30 is a 30-item subject self-report questionnaire composed of both multi-item and single scales, including global health status/quality of life, functional Scales (physical, role, emotional, cognitive, and social), symptom scales (fatigue, nausea and vomiting, and pain), and 6 single items (dyspnea, insomnia, appetite loss, constipation, diarrhea, and financial difficulties). Participants rate items on a 4-point scale, with 1 as "not at all" and 4 as "very much."
Change in patient-reported QoL, per EORTC QLQ-C30 in all participants Baseline to week 12 The EORTC-QLQ-C30 is a 30-item subject self-report questionnaire composed of both multi-item and single scales, including global health status/quality of life, functional Scales (physical, role, emotional, cognitive, and social), symptom scales (fatigue, nausea and vomiting, and pain), and 6 single items (dyspnea, insomnia, appetite loss, constipation, diarrhea, and financial difficulties). Participants rate items on a 4-point scale, with 1 as "not at all" and 4 as "very much."
Change in patient reported disease symptoms per EORTC Quality of Life Questionnaire-Multiple Myeloma (MM) module 20 [QLQ-MY20]) in participants previously exposed to CD38 antibodies Baseline to week 12 The EORTC QLQ-MY20 is a self -administered instrument to assess QoL in persons with MM. This 20-item questionnaire measures the following domains: symptom scales, including disease symptoms (6 items) and symptoms related to side effects of treatment (10 items); function scale and future perspective (3 items); and body image (1 item). A high score represents a high level of symptoms or problems.
Change in patient reported disease symptoms per EORTC QLQ-MY20 in all participants Baseline to week 12 The EORTC QLQ-MY20 is a self -administered instrument to assess QoL in persons with MM. This 20-item questionnaire measures the following domains: symptom scales, including disease symptoms (6 items) and symptoms related to side effects of treatment (10 items); function scale and future perspective (3 items); and body image (1 item). A high score represents a high level of symptoms or problems.
Patient-Reported Outcomes in Patient Global Impression of Symptom Severity (PGIS) in participants previously exposed to CD38 antibodies Baseline to week 12 The PGIS is a single 1-item questionnaire designed to assess participant's overall impression of disease severity at a given point in time by using a 4-point Likert scale that ranges from (1) = "none (no symptoms)" to (4) = "severe".
The global anchor, PGIS will be used for interpretation of EORTC QLQ-C30, EORTC QLQ-MY20, and BPI-SF.Patient-Reported Outcomes in PGIS in all participants Baseline to week 12 The PGIS is a single 1-item questionnaire designed to assess participant's overall impression of disease severity at a given point in time by using a 4-point Likert scale that ranges from (1) = "none (no symptoms)" to (4) = "severe".
The global anchor, PGIS will be used for interpretation of EORTC QLQ-C30, EORTC QLQ-MY20, and BPI-SF.Patient-Reported Outcomes in Patient Global Impression of Change (PGIC) in participants previously exposed to CD38 antibodies Baseline to week 12 The PGIC is a single-item questionnaire designed to assess the participant's overall sense of whether there has been a change since starting treatment as rated on a 5-point Likert scale anchored by (1) "much better" to (5) "much worse", with (4) = "no change".
The global anchor, PGIC will be used for interpretation of EORTC QLQ-C30, EORTC QLQ-MY20, and BPI-SF.Patient-Reported Outcomes in PGIC in all participants Baseline to week 12 The PGIC is a single-item questionnaire designed to assess the participant's overall sense of whether there has been a change since starting treatment as rated on a 5-point Likert scale anchored by (1) "much better" to (5) "much worse", with (4) = "no change".
The global anchor, PGIC will be used for interpretation of EORTC QLQ-C30, EORTC QLQ-MY20, and BPI-SF.Change in patient-reported general health status per EuroQoL-5 Dimension-5 Level Scale [EQ-5D-5L]) in participants previously exposed to CD38 antibodies Baseline to week 12 The EQ-5D-5L consists of EQ-5D descriptive system comprises five dimensions: mobility, self-care, usual activities, pain/discomfort and anxiety/depression. Each dimension has 5 levels: no problems, slight problems, moderate problems, severe problems and extreme problems.
Change in patient-reported general health status per EQ-5D-5L in all participants Baseline to week 12 The EQ-5D-5L consists of EQ-5D descriptive system comprises five dimensions: mobility, self-care, usual activities, pain/discomfort and anxiety/depression. Each dimension has 5 levels: no problems, slight problems, moderate problems, severe problems and extreme problems.
Trial Locations
- Locations (157)
The Tel Aviv Sourasky Medical Center
🇮🇱Tel Aviv, Israel
Instituto DOr de Pesquisa e Ensino
🇧🇷Sao Paulo, Brazil
AC Camargo Cancer Center
🇧🇷Sao Paulo, Brazil
Clinica Medica Sao Germano
🇧🇷Sao Paulo, Brazil
The Ottawa Hospital Cancer Centre
🇨🇦Ottawa, Ontario, Canada
IDOR - Sao Rafael Salvador Bahia
🇧🇷Salvador, Bahia, Brazil
Sheba Medical Center
🇮🇱Ramat Gan, Israel
Clinique Universitaire de Mont Godinne
🇧🇪Yvoir, Belgium
University of Washington
🇺🇸Seattle, Washington, United States
University of California Los Angeles (UCLA)
🇺🇸Los Angeles, California, United States
University of Florida
🇺🇸Gainesville, Florida, United States
University of Kentucky, Markey Cancer Center Clinical Research Organization
🇺🇸Lexington, Kentucky, United States
Norton Cancer Institute
🇺🇸Louisville, Kentucky, United States
Stony Brook University
🇺🇸Stony Brook, New York, United States
Levine Cancer Center
🇺🇸Charlotte, North Carolina, United States
Duke University Medical Center
🇺🇸Durham, North Carolina, United States
Kaiser Permanente Northwest
🇺🇸Portland, Oregon, United States
MD Anderson Cancer Center
🇺🇸Houston, Texas, United States
Royal Prince Alfred Hospital
🇦🇺Camperdown, New South Wales, Australia
Royal North Shore Hospital
🇦🇺St Leonards, New South Wales, Australia
Icon Cancer Centre - Wesley
🇦🇺Auchenflower, Queensland, Australia
Royal Brisbane and Women's Hospital
🇦🇺Herston, Queensland, Australia
Royal Adelaide Hospital
🇦🇺Adelaide, South Australia, Australia
Royal Hobart Hospital
🇦🇺Hobart, Tasmania, Australia
Launceston General Hospital
🇦🇺Launceston, Tasmania, Australia
St Vincent's Hospital
🇦🇺Fitzroy, Victoria, Australia
University Hospital Geelong
🇦🇺Geelong, Victoria, Australia
Austin Hospital
🇦🇺Heidelberg, Victoria, Australia
One Clinical Research at Hollywood Private Hospital
🇦🇺Nedlands, Western Australia, Australia
AZ Delta Algemeen Ziekenhuis Delta
🇧🇪Roeselare, West-Vlaanderen, Belgium
Ziekenhuis Netwerk Antwerpen Stuivenberg
🇧🇪Antwerp, Belgium
Cliniques Universitaires Saint-Luc
🇧🇪Bruxelles, Belgium
Hospital Erasto Gaertner
🇧🇷Curitiba, Parana, Brazil
Associacao Dr Bartholomeu Tacchini
🇧🇷Bento Goncalves, Rio Grande Do Sul, Brazil
Hospital de Clinicas de Porto Alegre
🇧🇷Porto Alegre, Rio Grande Do Sul, Brazil
Centro Gaucho Integrado
🇧🇷Porto Alegre, Rio Grande Do Sul, Brazil
Animi Unidade de Tratamento Oncologico
🇧🇷Centro, Brazil
Instituto Americas de Ensino e Pesquisa
🇧🇷Rio de Janeiro, Brazil
Hospital A Beneficencia Portuguesa de Sao Paulo
🇧🇷Sao Paulo, Brazil
Sunnybrook Health Sciences Centre
🇨🇦Toronto, Ontario, Canada
University Health Network-Princess Margaret Cancer Center
🇨🇦Toronto, Ontario, Canada
Hospital Clinico Universidad de Los Andes
🇨🇱Santiago, Las Condes, Chile
Clinica Alemana de Santiago
🇨🇱Santiago, Region Metropolitana, Chile
Fundacion Arturo Lopez Perez
🇨🇱Santiago, Region Metropolitana, Chile
Clinica UC San Carlos de Apoquindo
🇨🇱Santiago, Region Metropolitana, Chile
Centro Oncologia de Precision Universidad Mayor
🇨🇱Santiago, Region Metropolitana, Chile
Centro de Investigaciones Clinicas Vina del Mar
🇨🇱Vina del Mar, Valparaiso, Chile
Centre Leon Berard (CLB) - Centre de Recherche en Cancerologie Lyon-Est (CRCL)
🇫🇷Lyon, Auvergne-Rhone, France
Centre Francois Magendie
🇫🇷Pessac, Gironde, France
Centre Hospitalier Universitaire de Lille
🇫🇷Lille, Hauts De France, France
Gustave Roussy
🇫🇷Villejuif, Ile De France, France
Hopital Necker
🇫🇷Paris, Ile-de-France, France
Hopital Saint Louis, APHP
🇫🇷Paris, France
Hopital Saint Antoine
🇫🇷Paris, France
Institut Curie
🇫🇷Saint-Cloud, France
NHO Shibukawa Medical Center
🇯🇵Shibukawa, Gunma, Japan
Medical Clinic II
🇩🇪Tuebingen, Baden-Wuerttemberg, Germany
Universitat zu Lubeck Neuromuskulares Zentrum
🇩🇪Luebeck, Ratzeburger, Germany
University Hospital Hamburg Eppendorf
🇩🇪Hamburg, Germany
University Hospital Leipzig - Hematology and Cellular Therapy
🇩🇪Leipzig, Germany
Rambam Health Care Campus
🇮🇱Haifa, North, Israel
Lady Davis Carmel Medical Center
🇮🇱Haifa, Israel
Shaare Zedek Medical Center
🇮🇱Jerusalem, Israel
Hadassah Medical Center
🇮🇱Jerusalem, Israel
IRCCS Casa Sollievo della Sofferenza
🇮🇹San Giovanni Rotondo, Foggia, Italy
Istituto Romagnolo per lo Studio Dei Tumori Dino Amadori
🇮🇹Meldola, Forli Cesena, Italy
A.O.U. Citta della Salute e della Scienza di Torino
🇮🇹Torino, Piemonte, Italy
IRCCS Fondazione Piemontese Oncologica Candiolo
🇮🇹Candiolo, Torino, Italy
Azienda Ospedaliera Nazionale SS - Antonio e Biagio e Cesare Arrigo
🇮🇹Alessandria, Italy
AOU Ospedali Riuniti di Ancona
🇮🇹Ancona, Italy
Policlinico S. Orsola- Malpighi
🇮🇹Bologna, Italy
Azienda Ospedaliero Universitaria Policlinico "G. Rodolico - San Marco"
🇮🇹Catania, Italy
Ospedale Policlinico San Martino IRCCS
🇮🇹Genova, Italy
Universita degli Studi di Pavia - Fondazione IRCCS Policlini
🇮🇹Pavia, Italy
Ospedale Santa Maria delle Croci
🇮🇹Ravenna, Italy
AUSL IRCCS OF Reggio Emilia - Clinical Study Location -
🇮🇹Reggio Emilia, Italy
Ospedale di Circolo e Fondazione Macchi Varese
🇮🇹Varese, Italy
Kameda General Hospital
🇯🇵Kamogawa, Chiba, Japan
Kurume University Hospital
🇯🇵Kurume, Fukuoka, Japan
Ogaki Municipal Hospital
🇯🇵Ogaki, Gifu, Japan
Gunma University Hospital
🇯🇵Maebashi, Gunma, Japan
Sapporo Hokuyu Hospital
🇯🇵Sapporo, Hokkaido, Japan
Iwate Medical University Hospital
🇯🇵Morioka, Iwate, Japan
National Hospital Organization Okayama Medical Center
🇯🇵Kita-ku, Okayama, Japan
Osaka University Hospital
🇯🇵Suita-shi, Osaka, Japan
Saitama Medical University Hospital
🇯🇵Iruma-gun, Saitama, Japan
Chiba Cancer Center
🇯🇵Chiba-shi, Tiba, Japan
Tokushima Prefectural Central Hospital
🇯🇵Tokushima-shi, Tokushima, Japan
Hospital Universitario Virgen de Valme
🇪🇸Sevilla, Spain
Japanese Red Cross Medical Center
🇯🇵Shibuya-ku, Tokyo, Japan
Yamanashi Prefectural Central Hospital
🇯🇵Kofu, Yamanashi, Japan
Fukushima Medical University
🇯🇵Fukushima, Japan
National Hospital Organization Kumamoto Medical Center
🇯🇵Kumamoto, Japan
National Hospital Organization Sendai Medical Center
🇯🇵Sendai, Japan
Gachon University Gil Hospital
🇰🇷Incheon, Gyeonggi, Korea, Republic of
Jeonbuk National University Hospital
🇰🇷Jeonju, Jeollabuk-do, Korea, Republic of
Chonnam National University Hwasun Hospital
🇰🇷Hwasun, South Jeolla, Korea, Republic of
Inje University Busan Paik Hospital
🇰🇷Busan, Korea, Republic of
Pusan National University Hospital
🇰🇷Busan, Korea, Republic of
Asan Medical Center
🇰🇷Seoul, Korea, Republic of
Seoul St Marys Hospital
🇰🇷Seoul, Korea, Republic of
Samsung Medical Center
🇰🇷Seoul, Korea, Republic of
Seoul National University Hospital
🇰🇷Seoul, Korea, Republic of
Severance Hospital
🇰🇷Seoul, Korea, Republic of
Radboudumc
🇳🇱Nijmegen, Gelderland, Netherlands
Albert Schweitzer Hospital
🇳🇱Dordrecht, Zuid-Holland, Netherlands
Wielospecjalistyczne Centrum Onkologii i Traumatologii
🇵🇱Lodz, Lodzkie, Poland
University Clinical Center / Medical University of Gdansk
🇵🇱Gdansk, Pomorskie, Poland
Szpital Uniwersytecki Nr2 Bydgoszcz
🇵🇱Bydgoszcz, Poland
Pratia Onkologia Katowice
🇵🇱Katowice, Poland
Centrum Innowacyjnych Terapii Samodzielny Publiczny Szpital Kliniczny Nr 4 w Lublinie
🇵🇱Lublin, Poland
National University Hospital
🇸🇬Singapore, Singapore
Hospital Universitari i Politecnic La Fe
🇪🇸Valencia, Spain
Singapore General Hospital
🇸🇬Singapore, Singapore
Hospital Clinico Universitario Santiago de Compostela
🇪🇸Santiago de Compostela, A Coruna, Spain
Hospital Universitario Araba
🇪🇸Vitoria Gasteiz, Alava, Spain
University Hospital of Cabuenes
🇪🇸Gijon, Asturias, Spain
Hospital Universitario Central de Asturias
🇪🇸Oviedo, Asturias, Spain
Hospital Universitari Son Llatzer
🇪🇸Palma Mallorca, Baleares, Spain
Hospital Universitari Son Espases
🇪🇸Palma, Balearic Islands, Spain
Institut Catala d'Oncologia
🇪🇸Badalona, Barcelona, Spain
Hospital Universitari Mutua Terrassa
🇪🇸Terrassa, Barcelona, Spain
Hospital Universitario Marques de Valdecilla
🇪🇸Santander, Cantabria, Spain
Complejo Asistencial Universitario de Leon
🇪🇸Leon, Castilla Y Leon, Spain
Hospital General Universitario Doctor Balmis Alicante
🇪🇸Alicante, Comunidad Valenciana, Spain
Hospital Universitario Puerta de Hierro
🇪🇸Majadahonda, Madrid, Spain
Hospital Universitario Quironsalud Madrid
🇪🇸Pozuelo de Alarcon, Madrid, Spain
Clinica Universidad de Navarra
🇪🇸Pamplona, Navarra, Spain
Hospital Clinico Lozano Blesa
🇪🇸Zaragoza, Spain
Hospital Universitario de Navarra
🇪🇸Pamplona, Navarra, Spain
Universitary Hospital La Princesa
🇪🇸Madrid, Salamanca, Spain
Hospital Clinic de Barcelona
🇪🇸Barcelona, Spain
Hospital Sant Pau
🇪🇸Barcelona, Spain
Catalan Institute of Oncology (ICO) Hospitalet
🇪🇸Barcelona, Spain
Instituto Catalan Oncologia
🇪🇸Girona, Spain
Clinica Universidad de Navarra - Madrid
🇪🇸Madrid, Spain
Hospital Universitario Fundacion Jimenez Diaz
🇪🇸Madrid, Spain
Hospital Universitario La Paz
🇪🇸Madrid, Spain
Hospital Virgen de la Victoria
🇪🇸Malaga, Spain
Chang Gung Memorial Hospital - Linkou Branch
🇨🇳Taoyuan, Hunan Province, Taiwan
Changhua Christian Hospital
🇨🇳Changhua City, Taiwan
Hualien Tzu Chi Hospital
🇨🇳Hualien City, Taiwan
Kaohsiung Medical University Hospital
🇨🇳Kaohsiung, Taiwan
Kaohsiung Chang Gung Memorial Hospital
🇨🇳Kaohsiung, Taiwan
Taichung Veterans General Hospital
🇨🇳Taichung, Taiwan
National Cheng Kung University Hospital
🇨🇳Tainan City, Taiwan
Wanfang Hospital
🇨🇳Taipei, Taiwan
National Taiwan University Hospital
🇨🇳Taipei, Taiwan
Tri-Service General Hospital
🇨🇳Taipei, Taiwan
Addenbrooke's Hospital
🇬🇧Cambridge, Cambrigeshire, United Kingdom
Western General Hospital
🇬🇧Edinburgh, Scotland, United Kingdom
Queen Elizabeth Hospital Birmingham
🇬🇧Birmingham, West Midlands, United Kingdom
Barts Health NHS Trust
🇬🇧London, United Kingdom
Guy's & St Thomas' NHS Foundation Trust
🇬🇧London, United Kingdom
Royal Marsden Hospital
🇬🇧London, United Kingdom
Hammersmith Hospital
🇬🇧London, United Kingdom
The Christie NHS Foundation Trust
🇬🇧Manchester, United Kingdom