A RANDOMIZED PLACEBO CONTROLLED SINGLE BLIND PARALLEL TRIAL WITH PRE AND POST INTERVENTION BLOOD PLASMA ANALYSIS USING UV SPECTROPHOTOMETRY ALONGWITH WOMAC SCALE IN OSTEOARTHRITIS OF KNEE

This study is designed as a randomized, placebo-controlled, single-blind, parallel clinical trial to evaluate the effect of individualized homoeopathic treatment in patients with knee osteoarthritis. Participants will be randomly allocated into intervention and placebo control groups. Comprehensive case-taking will be carried out as per standard proforma, followed by baseline assessment using the WOMAC scale to evaluate pain, stiffness, and physical function. Blood samples will be collected before and after the intervention and processed to obtain blood plasma. UV–Visible spectrophotometric analysis will be performed on plasma samples to record absorbance patterns within a defined wavelength range. Post-intervention assessments will be conducted after a fixed treatment duration to observe changes. The WOMAC scale will be re-evaluated at regular follow-up intervals to assess clinical improvement. The placebo group will receive indistinguishable inert pills to ensure blinding. This design allows for objective biochemical evaluation along with subjective clinical assessment. The study aims to correlate changes in UV spectrophotometric absorbance with clinical outcomes. The purpose of the study is to explore the potential role of individualized homoeopathy in knee osteoarthritis and to generate scientific evidence through measurable laboratory parameters.