Cognitive and Brain Development in Adolescents With Gilles de la Tourette Syndrome
- Conditions
- Tourette Syndrome in Adolescence
- Interventions
- Behavioral: Behavioral testing on cognitive computerized tasksOther: brain MRIOther: TMS
- Registration Number
- NCT04179435
- Lead Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
- Brief Summary
In children with neurodevelopmental disorders, adolescence is usually associated with a reshaping of the clinical picture and symptomatology. Tourette syndrome (TS) is a paradigmal neurodevelopmental syndrome characterised by involuntary paroxysmal movements (motor tics) and vocalisation (vocal tics) often associated with various psychiatric disorders. The neuronal and cognitive mechanisms associated with TS symptoms improvement during adolescence, or the persistence in adulthood remains unknown, and this is what we aim to address in this study.
- Detailed Description
Thus, the aims of the present project is threefold:
Aim 1: To evaluate the maturation of cognitive functions in adolescents with TS compared to typically developing adolescents.
To achieve this aim, three distinct cognitive dimensions will be assessed in all subjects (patients and controls): (i) reward sensitivity and habit formation; (ii) cognitive impulsivity and action control and (iii) self-agency.
Aim 2: To identify neuronal correlates of cognitive function and brain development in health and disease. To achieve this aim, we will use a combined behavioural (as described in Aim 1), (i) neuroimaging and (ii) TMS approaches.
Aim 3: To predict clinical outcome . In this part of the project we aim to identify behavioural, imaging or neurophysiological markers of clinical outcome in patients with TS.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 132
- Tourette syndrome
- Ages 13 - 18
- Acceptance to perform the Brain MRI
- Acceptance to perform the cognitive testing
- Acceptance to perform the TMS measures
- Learning disability
- Incompatibility with MRI procedure (metal body implants, pregnancy)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Tourette syndrome brain MRI Patients with Tourette syndrome aged 13 - 18 y.o. Interventions : Brain scans, cognitive testing, TMS measures Tourette syndrome TMS Patients with Tourette syndrome aged 13 - 18 y.o. Interventions : Brain scans, cognitive testing, TMS measures Tourette syndrome Behavioral testing on cognitive computerized tasks Patients with Tourette syndrome aged 13 - 18 y.o. Interventions : Brain scans, cognitive testing, TMS measures Controls brain MRI Controls matched to Tourette syndrome group nterventions : Brain scans, cognitive testing, TMS measures Controls TMS Controls matched to Tourette syndrome group nterventions : Brain scans, cognitive testing, TMS measures Controls Behavioral testing on cognitive computerized tasks Controls matched to Tourette syndrome group nterventions : Brain scans, cognitive testing, TMS measures
- Primary Outcome Measures
Name Time Method Behavioral test main outcome measures [4] from 16 to 20 months agency composite scores
Behavioral test main outcome measures [2] from 16 to 20 months discounting factor
Behavioral test main outcome measures [3] from 16 to 20 months number of premature responses
Brain MRI scan measures from 16 to 20 months whole brain structural connectivity, whole brain functional connectivity, brain cortical and subcortical structures volumes and morphology
Behavioral test main outcome measures [1] from 16 to 20 months reaction times
Transcranial magnetic stimulation from 16 to 20 months intracortical inhibition (SICI) scores
- Secondary Outcome Measures
Name Time Method