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Clinical Trials/NCT02498730
NCT02498730CompletedNot Applicable

Can the High Intensity Interval Training (HIIT) Deliver Superior and Rapid Decrease of Symptoms of Bipolar Disorder? a Controlled and Randomized Study

Universidade Federal do Rio de Janeiro1 site in 1 country36 target enrollmentStarted: August 1, 2015Last updated:
Conditions
Interventions

Trial Snapshot

Phase
Not Applicable
Status
Completed
Enrollment
36
Locations
1
Primary Endpoint
Symptom Scales (Hamilton and Young)

Study Overview

Brief Summary

Our main objective will be to evaluate the chronic effects (12 weeks) of high-intensity interval training compared to moderate intensity (same total work) on reducing the symptoms of bipolar disorder, cortical changes, as well as on the VO2max. In addition, the investigators will establish what influence of gain to VO2max has on reducing symptoms.

Detailed Description

Physical exercise has significant effects on health promotion and the consequent reduction of the severity of bipolar disorder (BD). This review establishes a pattern of response of exercise and potential impact on the pathophysiology of BD; , as well as, produces hypotheses on how acute and chronic effect of exercises may act differently; and provides future perspectives with the focus of the exercise as an important and innovative model of treatment for BD and mental disorder. A critical evaluation of the literature was undertaken including the influence of exercise on health promotion in patients with mental disorders, neurochemical behavior exercise-induced, as well as reflective introduction of news perspectives of training control in severe exercise domain. The exercise induces significant changes in monoaminergic after, and with long-term training, and work with a threshold of exercise can modulate positive effects on mood. Fast adaptive effects from the high intensity interval training should be considered in BD patients. However, there must be caution in his administration. We speculate that exercise may be a way of maintaining euthymia in the case of BD, making it less vulnerable patient to stay longer at a time of neutrality. Future research is needed to adopt a training strategy that is both time efficient in the different areas and adequate for the population in question.

Study Design

Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel
Primary Purpose
Treatment
Masking
None

Eligibility Criteria

Ages
18 Years to 59 Years (Adult)
Sex
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • Bipolar Criteria (DSM-IV),
  • sedentary lifestyle

Exclusion Criteria

  • 60 and over,
  • Cardiovascular Disease,
  • Panic disorder,
  • Metabolic syndrome Diagnosis

Arms & Interventions

Continuous Training

Active Comparator

Running at 60% VO2Max, 25 minutes (total exercise), 3 times/week, 12 weeks

Intervention: Interval Training (Behavioral)

Interval Training

Active Comparator

6 stimulous (30 s) at 100% VO2Max/ 1 min 30 s to rest, 19 minutes (total exercise), 3 times/ week, 12 weeks

Intervention: Interval Training (Behavioral)

Interval Training

Active Comparator

6 stimulous (30 s) at 100% VO2Max/ 1 min 30 s to rest, 19 minutes (total exercise), 3 times/ week, 12 weeks

Intervention: Continuous Training (Behavioral)

Continuous Training

Active Comparator

Running at 60% VO2Max, 25 minutes (total exercise), 3 times/week, 12 weeks

Intervention: Continuous Training (Behavioral)

Control

Sham Comparator

Only Dependent Variables Measures

Intervention: Control (Behavioral)

Outcomes

Primary Outcomes

Symptom Scales (Hamilton and Young)

Time Frame: 0 week, 6 week, 12 week

Variable Measured to reduction of symptoms

Secondary Outcomes

  • Cortical Changes (EEG) - Loreta(0 week, 6 week, 12 week)
  • Cognitive Function(0 week, 6 week, 12 week)
  • VO2Max(0 week, 6 week, 12 week)

Investigators

Sponsor Class
Other
Responsible Party
Principal Investigator
Principal Investigator

Alberto Souza de Sá Filho

Doctorade in Mental Health

Universidade Federal do Rio de Janeiro

Study Sites (1)

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