Chest Compression and Sustained Inflation for Asystole or Bradycardia in Newborn Infants
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- University of Alberta
- Enrollment
- 9
- Locations
- 1
- Primary Endpoint
- Time Needed to Achieve Return of Spontaneous Circulation
Study Overview
Brief Summary
Guidelines on neonatal resuscitation recommend 90 chest compressions (CC) and 30 manual inflations (3:1) per minute in newborns. The study aimed to determine if CC s during sustained inflations (SI) improves recovery of asphyxiated newborns compared to coordinated 3:1 resuscitation.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Single Group
- Primary Purpose
- Treatment
- Masking
- Single (Outcomes Assessor)
Eligibility Criteria
- Ages
- — to 3 Months (Child)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Newborn infants with asystole Newborn infants with bradycardia
Exclusion Criteria
- Not provided
Arms & Interventions
3:1 CPR
CPR using 3:1 C:V ratio:
"3:1 C:V group" Infants randomized into the "3:1 group" requiring CC, would received CC using the current 3:1 C:V ratio recommend in the neonatal resuscitation guidelines16. Every 45 sec the clinical team would assess heart rate. 3:1 C:V CPR was continued until ROSC.
Intervention: 3:1 CPR (Procedure)
SI+CC
Chest compression will be superimposed by sustained inflations during CPR:
"CC+SI group" Infants randomized in the SI group requiring CC, would receive CC at a rate of 90/min during an SI with a duration of 20sec (CC+SI). After 20 sec the SI will be interrupted for 1 sec and the next SI will be started for another 20sec13. Throughout this time CC is continued until ROSC. Every 45 sec (approximately 2 SIs) the clinical team would assess for changes in heart rate. CC+SI was continued until ROSC.
Intervention: CC+SI (Procedure)
Outcomes
Primary Outcomes
Time Needed to Achieve Return of Spontaneous Circulation
Time Frame: within the first 10 minutes after birth
We aim to reduce time needed to achieve Return of Spontaneous Circulation. This should be achieved by the experimental chest compression technique
Secondary Outcomes
No secondary outcomes reported