Evaluation of Power Doppler US Technique for the Diagnosis of Spondylarthropathy

Completed

• Conditions: Spondylarthropathy; Spondyloarthritis; Ankylosing Spondyloarthitis

• Registration Number: NCT00794404
• Lead Sponsor: Dr Maria-Atonietta D'AGOSTINO

Brief Summary

The purpose of this study is to evaluate the interest of enthesis sonography for the diagnosis of spondylarthritis, in patients with uncertain diagnosis consulting for clinical symptoms suggestive of spondylarthritis

Detailed Description

Spondylarthritis (SPA) are the second most frequent inflammatory rheumatic disorders and, because it starts early in life and has a chronic progressive course, the impact of this disease on health resources and patient's life quality can be important. Because the characteritic signs of SPA, like radiological evidence of sacro-iliitis, appear late in time, the lag time between the onset first signs of SPA for the patient and the confirmed diagnosis can be very long (up to 8 years). Previous studies proved that patients who are affected by SPA are showing abnormal vascularization of peripheral enthesis more frequently than patients affected by other rheumatic diseases. Ultrasonography in B mode combined with power Doppler (PDUS) is a non invasive and highly sensitive toll which can detect enthesitis and abnormal vsacularization even for the patients who are not showing yet the evidence of SPA's symptomatology. Using PDUS as a early diagnosis tool could lead to the improvement of diagnostic procedures and therapeutic management of SpA and reduce the cost of diagnosis for patient and health insurances.

Study Timeline

• Study Start: 2004-12
• Status Verified: 2008-11
• Study First Submitted: 2008-11-19
• Study First Submitted QC: 2008-11-19
• Study First Posted: 2008-11-20
• Primary Completion: 2010-03
• Study Completion: 2010-12
• Last Update Submitted: 2016-10-28
• Last Update Posted: 2016-10-31

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 489

Inclusion Criteria

• patients < 50 years old, consulting for spinal inflammatory symptoms > 3 months duration
• patients consulting for arthritis or tenderness joints > 3 months duration
• patients < 50 years old consulting for enthesitis or dactylitis > 3 months duration
• patients with uveitis and HLA-B27 positivity
• relatives of SpA patients consulting for symptoms suggestive of SpA

Exclusion Criteria

• patient with confirmed diagnosis of rheumatic disease (included SpA)
• patient protected by law (patient <18 years old, pregnant woman)
• patient who can't atempt the RMI
• patient who will have difficulties to complete the two years of follow-up

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Trial Locations

Locations (6)

Ambroise Paré Hospital; 🇫🇷 Boulogne Billancourt, France

South Hospital of Grenoble; 🇫🇷 Echirolles, France

Nancy Brabois Hospital; 🇫🇷 VANDOEUVRE les NANCY, France

Conception Hospital; 🇫🇷 Marseille, France

Cavale Blanche Hospital; 🇫🇷 Brest, France

Cote de Nacre Hospital; 🇫🇷 Caen, France