Multimodal single-cell profiling for hip osteoarthritis
Recruiting
- Conditions
- Osteoarthritis
- Registration Number
- DRKS00034164
- Lead Sponsor
- udwig-Maximilians-Universität München-Klinikum, Klinik für Orthopädie und Unfallchirurgie, Muskuloskelettales Universitätszentrum München (MUM)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
Only inclusion of white Europeans to initially determine genetic changes within a specific ethnic group.
Exclusion Criteria
Infections, necrosis of the femoral head, disorders of bone metabolism, rheumatoid arthritis or other inflammatory arthritis, post-traumatic osteoarthritis, treatment with bisphosphonates, lupus, gout, pregnancy
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Identifying gene expression and regulatory changes in hip osteoarthritis at the single cell level.
- Secondary Outcome Measures
Name Time Method Create an atlas of single cell expression and chromatin accessibility which can provide new insights into processes that regulate the pathogenesis of hip osteoarthritis.