Recording Sympathetic Nerve Activity From the Skin During Surgery Under General Anesthesia : a Pilot Study
Overview
- Phase
- Not Applicable
- Intervention
- Rocuronium
- Conditions
- Skin Sympathetic Nerve Activity During General Anesthesia in Patients Undergoing Breast Cancer Surgery
- Sponsor
- Seoul National University Hospital
- Enrollment
- 20
- Locations
- 1
- Primary Endpoint
- The skin sympathetic nerve activity presented as uV obtained via skin leads.
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
Sympathetic nerve activity can be measured transcutaneously in awake patients by computer-based filtering of raw signal obtained via skin leads attached on the chest. Electrocardiogram can be removed by applying a high-pass filter setting of 150 Hz. Electromyogram can be filtered by applying a high-pass filter setting of 500 Hz or a band-pass filter setting of 500-1000 Hz.
However, it is not known whether the skin sympathetic nerve activity (SKNA) can be measured in anesthetized and/or paralyzed patients. Therefore, we planned this pilot study to observe whether the SKNA can be obtained in these patients. If the SKNA ca be observed, it will be presented in milivolt (uV).
Investigators
Yunseok Jeon
Professor
Seoul National University Hospital
Eligibility Criteria
Inclusion Criteria
- •patients scheduled to undergo resection of breast cancer under general anesthesia after insertion of laryngeal mask airway
Exclusion Criteria
- •Autonomic nervous system disease
- •Medication acting on the autonomic nervous system
- •Refuse to participate
Arms & Interventions
ROC
Neuromuscular blockade is performed in the ROC group by administering rocuronium 0.4\~0.8mg/kg before the insertion of laryngeal airway.
Intervention: Rocuronium
Outcomes
Primary Outcomes
The skin sympathetic nerve activity presented as uV obtained via skin leads.
Time Frame: During surgery/anesthesia
A few studies reported that skin sympathetic nerve activity (SKNA) signal could be potentially observed by applying a high-pass filter of 500 Hz or a band-pass filter of 500\~1000 Hz to electric signal from skin leads attached on the skin of the chest in awake volunteers. However, it is not known if it would be also possible to observe the SKNA signal in anesthetized patients. Also, there is no established method for quantitative or qualitative assessment of the SKNA signal.