NL-OMON20015尚未招募不适用
Efficacy and feasibility of intranasal ketamine on acute suicidality, a multicenter double blind randomized placebo-controlled trial -pilot
niversity Medical Center Groningen (UMCG)0 个研究点目标入组 12 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 12
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
入选标准
- •Acute suicidality: suicidal thoughts and/or behaviour have increased within the last 24 hours.
- •BSSI score = 7
- •Subjects are in the age of 18-70
排除标准
- •Earlier participation in this study
- •Psychosis (as a primary diagnosis) (depression with psychotic features will not be an exclusion criterion per se).
- •Schizophrenia or another primary psychotic disorder
- •History of PCP- or ketamine addiction
- •Being under influence of GHB (Substance abuse in the (recent) history is not an exclusion criterion per se (with the exception of current GHB-intoxication and a high blood alcohol concentration, and intoxications leading to medical unstable conditions). Use of GHB will be assessed by asking the participant, since urinary analysis is relatively unreliable, and waiting for results of the blood test will, given the acute nature of this study, be too time consuming.
- •A blood alcohol concentration (BAC) of > 0.05%
- •Clinically significant and unstable infectious, immunological, neurological cardiovascular, gastro-intestinal, pulmonary, renal, ophthalmological (glaucoma), hepatic, endocrine or haematological disorder, a myocardial infarction, micturition problems or a complex surgical problem that needs immediate attention.
- •Presence of any contra-indication for ketamine use, such as severe high blood pressure, a recent myocardial infarction or relevant cardiac problems, severe thyroid problems, severe liver problems, severe kidney problems, epilepsy and increased intracranial pressure.
- •A known hypersensitivity for ketamine
- •Concomitant use of a MAO-inhibitor
- •Severe nose congestion or nasal polyps
- •Pregnancy or giving breastfeeding
- •Women in the reproductive age using unreliable contraception
- •Being unable to answer the questionnaires
- •Legal incompetency with regard to participation in this study
- •No informed consent
研究者
相似试验
进行中（未招募）
1 期
Efficacy of ketamine nose-spray on acute suicidal thoughts and behaviouEUCTR2020-002905-24-NLniversity Medical Center Groningen112
已完成
4 期
A study of the effectiveness of intranasal ketamine in the treatment of moderate to severe pain in the emergency departmentacute painInjuries and Accidents - Other injuries and accidentsAnaesthesiology - Pain managementACTRN12611001102965Southern Health150
已完成
2 期
Effect of Nasal Ketamine in Patients with Cataract SurgeryAge-related cataractIRCT20200605047662N2Esfahan University of Medical Sciences90
已完成
3 期
Comparison of Ketamine and Morphine in Pain ReliefIRCT20140524017812N4Tabriz University of Medical Sciences153
尚未招募
2 期
Effect of giving ketamine nebulization before surgery to reduce occurance of throat pain due to tracheal intubation after surgeryCTRI/2020/08/027327SSG HospitalVadodara