NL-OMON47603招募中不适用
The in vivo mechanisms that control migration of pathogenic dermal T-cells to synovial joints during psoriatic arthritis: the role of dermal lymphatic vessels. - T-cell migration from skin to joints in psoriatic arthritis.
Maasstadziekenhuis0 个研究点目标入组 101 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 101
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •Inclusion criteria psoriasis patients:
- •- patients that are diagnosed with psoriasis by their dermatologist
- •- age * 18 years
- •- written informed consent by the patient;Inclusion criteria psoriatic arthritis patients:
- •- Psoriasis patients that are diagnosed with psoriatic arthritis by their rheumatologist (according
- •to the CASPAR criteria)
- •- age * 18 years
- •- written informed consent by the patient;Inclusion criteria healthy volunteer:
- •- age * 18 years
- •- WHO performance score 0
- •- age and sex matched (for psoriasis and psoriatic arthritis)
- •- written informed consent ;Inclusion criteria systemic sclerosis patients:
- •- Patients that are diagnosed with systemic sclerosis by their rheumatologist
- •- age * 18 years
- •- written informed consent given by the patient;Inclusion criteria systemic lupus erythematodes patients:
- •- Patients that are diagnosed with systemic lupus erythematodes by their rheumatologist
- •- age * 18 years
- •- written informed consent given by the patient;Inclusion criteria vasculitis patients with skin involvement:
- •- Patients that are diagnosed with vasculitis by their rheumatologist
- •- age * 18 years
- •- written informed consent given by the patient;Human tissues;Inclusion criteria for tissue donors, ie. skin tissue: patients undergoing eyelid surgery; mammareduction/abdominoplasty; synovial tissue: knee-replacement therapy in PsA and osteoarthritis (orthopedic surgery), synovectomy wrist (plastic surgery)
- •- donors will be asked for their permission to use their materials anonymously; this will be recorded in their medical file.;Inclusion criteria for tissue donors, ie. patients undergoing vascular surgery. The 3 categories of vascular surgery patients that will be included are patients undergoing crossectomy in chronic venous insufficiency; carotid endarterectomy, and surgical bypass of aortoiliac occlusive disease in patients with intermittent claudicatio without any signs of infection or critical (limb) ischemia.
- •- written informed consent given by the patient
排除标准
- •- use of corticosteroids including topical or systemic for the last 6 weeks
- •- use of disease-modifying antirheumatic drugs (DMARDs) or immune-suppressive drugs
- •for the last 6 weeks
- •- concomitant use of drugs affecting the lymphatic system and/or immune responses
- •including non-steroidal anti-inflammatory drugs (NSAIDs), drugs targeting RAAS system,
- •and anti-allergy medication. These agents must be discontinued at least 6 weeks before
- •the screening visit.
- •- co-existence of chronic inflammatory disorders including eczema, asthma or chronic
- •- pregnancy
- •- active cancer
- •- any lymphatic, cardiovascular or immunodeficiency disorder
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