Clinical Outcomes of Enamel Matrix Derivative and Connective Tissue Graft in Modified Coronally Advanced Tunnel: A Randomized Controlled Trial
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Gingival Recession
- Sponsor
- Necmettin Erbakan University
- Enrollment
- 52
- Locations
- 1
- Primary Endpoint
- Percentage of Root Surface Coverage (%RC)
- Status
- Completed
- Last Updated
- 10 months ago
Overview
Brief Summary
This study investigates the treatment of gingival recession (specifically Miller Class I and II defects) using a minimally invasive surgical approach known as the modified coronally advanced tunnel (MCAT) technique. Participants are allocated into three groups: one receiving subepithelial connective tissue grafts (SCTG), another treated with enamel matrix derivatives (EMD), and a third group receiving a combination of SCTG and EMD.
The primary objective is to evaluate the clinical effectiveness of each treatment modality in terms of root coverage, esthetic outcomes, and postoperative patient comfort. The study also aims to determine whether the combined use of SCTG and EMD provides superior clinical results compared to their individual application. Both short-term and long-term treatment outcomes are assessed to identify the most effective approach for managing gingival recession.
Detailed Description
This randomized controlled clinical trial aims to evaluate both the short- and long-term clinical outcomes of the modified coronally advanced tunnel (MCAT) technique combined with various biomaterials in the treatment of Miller Class I and II gingival recession defects. A total of 60 systemically healthy individuals, aged between 18 and 60 years, presenting to the Department of Periodontology at Necmettin Erbakan University Faculty of Dentistry with gingival recession complaints will be included. Prior to enrollment, all participants will undergo routine periodontal examinations and nonsurgical Phase I therapy. Standard mucogingival procedures are routinely performed at this institution. Participants will be randomly assigned to one of the following three treatment groups (n=20 each): Group 1: MCAT + subepithelial connective tissue graft (SCTG) Group 2: MCAT + enamel matrix derivative (EMD) Group 3: MCAT + SCTG + EMD Clinical Evaluations Clinical assessments will be conducted at baseline, 3 months, and 6 months postoperatively and will include the following parameters: Plaque Index (PI): Assessed according to Silness and Löe (1964). Gingival Index (GI): Assessed according to Löe and Silness (1963). Gingival Recession Width (GRW): Measured horizontally at the widest point. Gingival Recession Height (GRH): Measured from the cementoenamel junction (CEJ) to the gingival margin. Keratinized Tissue Width (KTW): Measured from the gingival margin to the mucogingival junction. Probing Depth (PD) and Clinical Attachment Level (CAL): Measured at baseline and 6 months. PD is recorded from the gingival margin to the apical extent of the sulcus; CAL is measured from the CEJ to the base of the sulcus. Intraoral Photographs: Captured at all evaluation time points. Gingival thickness will be assessed under topical anesthesia at the mid-buccal aspect, 2 mm apical to the gingival margin, using an endodontic file fitted with a rubber stopper. The distance from the file tip to the stopper will be recorded using a digital caliper. The percentage of root coverage will be calculated based on clinical measurements, following the standardized formula described by Al-Hamdan et al. (2003). Wound Healing Evaluation: Sutures will be removed on postoperative day 14. Wound healing will be assessed individually for each treated site using the wound healing index proposed by Huang et al. (2005). This study aims to provide comprehensive insights into the clinical effectiveness, esthetic outcomes, and patient-reported comfort associated with the MCAT technique when used alone or in combination with SCTG and/or EMD for the treatment of gingival recession defects.
Investigators
Fatma Altıparmak
DDS, Research Assistant in the Department of Periodontology
Necmettin Erbakan University
Eligibility Criteria
Inclusion Criteria
- •Adults aged between 18 and 60 years
- •Systemically and periodontally healthy individuals
- •Non-smokers
- •Presence of a clearly detectable cementoenamel junction (CEJ)
- •No prior surgical intervention at the selected sites
- •No periodontal pockets deeper than 3 mm
- •No signs of occlusal trauma
Exclusion Criteria
- •Pregnancy or lactation
- •Use of antibiotics in the past 6 months
- •Presence of any systemic condition that may contraindicate periodontal surgery, including:
- •Diabetes mellitus
- •Impaired glucose tolerance
- •Endocrine disorders
- •Cardiovascular diseases
- •Declined to participate or failed to meet inclusion criteria
Outcomes
Primary Outcomes
Percentage of Root Surface Coverage (%RC)
Time Frame: 6 months postoperatively
The percentage of root surface coverage will be calculated based on changes in the exposed root surface area before and after treatment. The exposed area is estimated by multiplying the height and width of the gingival recession. The difference between the baseline and 6-month postoperative values will be used to determine the percentage of coverage. Results will be expressed as a percentage (%). This approach reflects the clinical effectiveness of the intervention and is based on the method described by Al-Hamdan et al. (2003).
Secondary Outcomes
- Gingival Index (GI)(Baseline, 1, 3, and 6 months postoperatively)
- Plaque Index (PI)(Baseline, 1, 3, and 6 months postoperatively.)
- Gingival Recession Height (GRH)(Baseline, 1, 3, and 6 months postoperatively)
- Gingival Recession Width (GRW)(Baseline, 1, 3, and 6 months postoperatively.)
- Clinical Attachment Level (CAL)(Baseline and 6 months postoperatively.)
- Keratinized Tissue Width (KTW)(Baseline, 1, 3, and 6 months postoperatively.)
- Gingival Thickness(Baseline and 6 months postoperatively.)
- Wound Healing Index (WHI)(2 weeks postoperatively.)
- Probing Depth (PD)(Baseline and 6 months postoperatively.)