Effect of Helicobacter Pylori Eradication on Gastroesophageal RefIux Disease (GERD)

Recruiting

• Conditions: GERD

• Registration Number: NCT06457334
• Lead Sponsor: Assiut University

Brief Summary

Evaluate the effect of H.pylori eradication on Gastroesophageal-reflux disease and symptoms improvement

Detailed Description

HeIicobacter PyIori (H.pyIori) is a gram-negative spiral shaped bacterium that affects up to 50% of the population worldwide, with a higher prevalences in the developing countries,Gastroesophageal reflux disease (GERD) is a chronic gastrointestinal disorder characterized by the regurgitation of gastric contents into the esophagus, resulting in a significant economic burden in direct and indirect costs and adversely affects the quality of life.GERD is caused by multiple different mechanisms that can be intrinsic, structural, or both, leading to the disruption of the esophago-gastric junction barrier resulting in exposure of the esophagus to acidic gastric contents, Clinically, GERD typically manifests with symptoms of heartburn and regurgitation. It can also present in an atypical fashion with extra-esophageal symptoms such as chest pain, dental erosions, chronic cough, laryngitis, or asthma.The relationship between H. pylori and gastroesophageal reflux disease (GERD) is still unclear, and the effect of H. pylori eradication on GERD treatment is unknown.Several studies have shown the inverse relationship between the occurrence of GERD and H.pyIori infection, in particular an increased severity of the disease is documented in patients with pre-existing symptoms .It has been showed that a markedly resolution of dyspepsia in patients at whom the eradication therapy was successful when compared with subjects with a persistent infection

Study Timeline

• Study Start: 2024-01-01
• Study First Submitted: 2024-05-27
• Status Verified: 2024-06
• Study First Submitted QC: 2024-06-09
• Last Update Submitted: 2024-06-09
• Study First Posted: 2024-06-13
• Last Update Posted: 2024-06-13
• Primary Completion: 2024-12-31
• Study Completion: 2025-01-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• All patients diagnosed as GERD clinically and endscopically.

Exclusion Criteria

• NO exclusion criteria

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Effect of Helicobacter pylori eradication on Gastroesophageal RefIux disease (GERD) syptomes	1\2024 to 12\2024	Evaluate the effect of H.pylori eradication on Gastroesophageal-reflux disease and correlate with GERD symptoms improvement.
Eradication of Helicobacter pylori after triple therapy	1\2024 to 12\2024	H.pylori eradication will be assessed using the endoscope

Trial Locations

Locations (1)

Alrajhi Hospital; 🇪🇬 Assiut, Egypt