Prolonging muscle paralysis after surgery: a comparative age-matched study

Completed

• Conditions: Post-operative residual neuromuscular blockade; Nervous System Diseases

• Registration Number: ISRCTN14366665
• Lead Sponsor: First Affiliated Hospital of Dalian Medical University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2017-06-02
• Last Update Posted: 4 September 2017

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 237

Inclusion Criteria

1. Patients with American Society of Anesthesiologists (ASA) physical status I-III scheduled to undergo elective surgery undergo general with muscle relaxants
2. Patients within the age groups 2-10, 18-64 and 65+ years

Exclusion Criteria

1. Patients with muscular disorders
2. Patients with neurological deficit
3. Patient refusal to consent
4. Patients scheduled to undergo prolong surgical procedures
5. Patients with severe impaired liver and renal function
6. Infants under 2 years
7. Patients with asthma
8. Patients with diabetes mellitus

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Residual neuromuscular blockade (RNMB), defined as train-of-four (TOF) ratio of less than 0.9. Moderate (TOF ratio = 0.7 but < 0.9) and severe (TOF ratio ? 0.7) PRNMB, is assessed 5 minutes to administration of cisatracurium at induction of general anesthesia, 1 minute interval after cisatracurium injection until 6 minutes and every 15 minutes in the postanesthetic care unit (PACU) until discharge.

Secondary Outcome Measures

Name	Time	Method
1. Demographic and patient characteristics such as age, weight, sex and co-morbidities, airway obstruction, indication of surgery, anesthesia duration, time (minutes) to PACU discharge and respiratory complications during hospital admission and length of hospital admission (days)<br>2. Total crystalloids and colloids volume (mls), total cisatracurium (mg) and total neostigmine (mg) <br>3. Perioperative and PACU temperature (?) monitoring during perioperative and PACU periods<br>4. Peripheral oxygen saturation (SpO2) monitoring during perioperative and PACU periods<br>5. End tidal carbon dioxide (EtCO2) monitoring during perioperative and PACU periods<br>6. Heart rate, systolic, diastolic and mean arterial pressure (mmHg) monitoring during perioperative and PACU periods.<br>7. Bispectral index (BIS) monitoring perioperative and PACU periods