Aerobic Exercise Intervention for Knee Osteoarthritis

Not Applicable

Completed

• Conditions: Osteoarthritis
• Interventions: Behavioral: Walking exercise; Behavioral: Cycling Exercise

• Registration Number: NCT00049816
• Lead Sponsor: Mayo Clinic

Brief Summary

This trial will test if walking or bicycling exercise is effective as a non-surgical treatment option for patients with knee osteoarthritis.

Detailed Description

Traditional, conservative medical treatment of osteoarthritis has been directed at improving functional status through reducing joint pain and inflammation and maintaining or restoring joint function. Exercise is an adjunct therapy in the clinical management of patients with osteoarthritis of the knee. However, it is not uniformly accepted. The central hypothesis of this work is that the Surgeon General's exercise guidelines can be successfully implemented as an effective nonsurgical option for treatment of patients with early stages of knee osteoarthritis.

Patients with knee osteoarthritis will be randomized into a control group, a walking exercise group, and a stationary cycling exercise group. The individuals in the exercise groups will be required to exercise three times per week for one year using emerging public health recommendations for aerobic exercise in the adult and aging population. Patient outcome will be assessed using objective gait analysis measurements, knee radiographs to quantify joint space narrowing, magnetic resonance imaging, a general health questionnaire (SF-36), a disease/site specific questionnaire (WOMAC), and a visual-analog pain scale. All subjects will be studied at 0 and 52 weeks.

Study Timeline

• Study Start: 2002-10
• Study First Submitted: 2002-11-14
• Study First Submitted QC: 2002-11-14
• Study First Posted: 2002-11-15
• Primary Completion: 2007-04
• Study Completion: 2007-04
• Status Verified: 2013-05
• Last Update Submitted: 2013-05-16
• Last Update Posted: 2013-05-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 306

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
2	Walking exercise	Participants will partake in a walking exercise program.
3	Cycling Exercise	Participants will partake in a cycling exercise program.

Primary Outcome Measures

Name	Time	Method
VAS, SF-36, WOMAC, and Activity Index questionnaires	Week 52
Weight-bearing anterior-posterior (AP) and lateral x-rays of the knee	Week 52
MRI imaging of the knee	Week 52
Measurements of gait during level walking and stair climbing	Week 52

Secondary Outcome Measures

Name	Time	Method
Change in consumption of analgesics, reflecting the level of joint pain	Week 52

Trial Locations

Locations (1)

Mayo Clinic; 🇺🇸 Rochester, Minnesota, United States