Specific Respiratory Infections as Triggers of Acute Medical Events: Time Series Analysis Using LabBase and Hospital Episode Statistics
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 787,000
- 试验地点
- 1
- 主要终点
- Acute myocardial infarction
研究概览
简要总结
This study will investigate whether there is a population-level association between circulating respiratory viruses and NHS hospital admissions for acute vascular events using data from national infection surveillance and Hospital Episode Statistics.
详细描述
We will conduct a time series study correlating anonymised population level data on all samples from NHS laboratories testing positive for six common respiratory viruses with admissions to NHS hospitals in England for a range of cardiac and vascular outcomes over the time period 01/01/2004 to 31/12/2014. This will involve generating Poisson regression models controlling for factors such as seasonal and long-term trends, environmental temperature and humidity.
This study is funded by an Academy of Medical Sciences Starter Grant for Clinical Lecturers.
研究设计
- 研究类型
- Observational
- 观察模型
- Ecologic Or Community
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 45 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Any individual with a record of an eligible outcome (ICD-10 coded hospitalisation for myocardial infarction or stroke) within the study period aged 45+ years
- •Any individual with a record of an eligible exposure (laboratory-confirmed respiratory virus) within the study period at any age
排除标准
- •Outcome events occurring in people aged <45 years
结局指标
主要结局
Acute myocardial infarction
时间窗: 01/01/2004 to 31/12/2014
ICD-10 coded
Stroke
时间窗: 01/01/2004 to 31/12/2014
ICD-10 coded
次要结局
未报告次要终点