NL-OMON52587招募中不适用
ALS-Electrode: Novel Neuro-electrical Biomarkers of Heterogeneous Network Degeneration in Amyotrophic Lateral Sclerosis for Quantifying the Progression and Outcome in Clinical Trials - ALS-Electrode
niversitair Medisch Centrum Utrecht0 个研究点目标入组 330 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 330
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •1. Belong to one cohort of interest
- •a. ALS patients: definite, probable, probable-laboratory supported or possible
- •ALS according to the revised El Escorial criteria (Brooks et al., 2000)
- •b. PMA/PLS patients: patients with clinical diagnosis of PMA or PLS, after
- •excluding other diseases.
- •c. Asymptomatic carriers: Carriers of ALS-related gene mutations with no
- •neurological symptoms associated with ALS
- •d. Healthy controls: age- and gender-matched to patient groups, intact physical
- •ability to take part in the experiment
- •2. Age 18-80 years (inclusive)
- •3. Capable of thoroughly understanding the study information given; has signed
- •the informed consent.
排除标准
- •Exclusion criteria for all participants:
- •Pregnancy
- •History of major head trauma
- •Any medical condition associated with neuropathy (e.g. diabetes), transient
- •ischemic attack, stroke, epilepsy, seizure disorder, brain tumours and other
- •comorbidities (e.g. human immunodeficiency virus)
- •Alcohol dependence syndrome, current use of neuroleptic medications or high
- •dose psychoactive medication
- •History of reaction or allergy to recording environments, equipment and the
- •recording gels
- •Tracheostomy, tracheostomal ventilation of any type or frequent need for
- •(non)-invasive ventilation
- •Further exclusion criteria for patients:
- •Insufficient dominant hand function to perform button pressing (SART/Stroop)
- •and/or motor tasks
- •Further exclusion criteria for healthy controls and asymptomatic carriers:
- •History of neuromuscular, neurological or active psychiatric disease.
研究者
相似试验
已完成
不适用
Spinal Interneuron Excitability in ALSALSNCT02429492Institut National de la Santé Et de la Recherche Médicale, France101
招募中
不适用
ALS biomarker researchamyotrophic lateral sclerosis (ALS)ALSJPRN-jRCTs051180229Inoue Haruhisa49
已完成
不适用
Quantitative Neuromuscular Ultrasonography in Amyotrophic Lateral Sclerosis (ALS)Amyotrophic Lateral SclerosisNCT02507713Universidad Católica San Antonio de Murcia60
Unknown
不适用
EEG and TMS-based Biomarkers of ALS, MS and FTDAmyotrophic Lateral SclerosisMultiple SclerosisFrontotemporal DementiaNCT04918251University of Dublin, Trinity College400
尚未招募
不适用
Assessment of clinical neurophysiological biomarkers for the differentiation of neurodegenerative disease versus non-neurological disorder in patients with mild cognitive impairment.intellectual disabilitycognitive disordersmild cognitive impairmentNL-OMON56487Centre for Human Drug Research30