ISRCTN07263575已完成不适用
Efficacy of inhaled recombinant human deoxyribonuclease in mechanically ventilated pediatric patients with an atelectasis
Erasmus Medical Center, Sophia Children's Hospital (Netherlands)0 个研究点目标入组 80 人开始时间: 2006年9月28日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 80
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •1. Aged zero to 18 years
- •2. Mechanical ventilation
- •3. Presence of an atelectasis on a chest radiograph
- •4. First dose of study medication can be administered preferably within six hours (maximum 12 hours) after an atelectasis has been diagnosed
排除标准
- •1. Children with neuromuscular disorders and impaired ability to cough, cardiomyopathy, or cystic fibrosis
- •2. Post-gestational age less than 32 weeks
- •3. Mechanical ventilation during muscle paralysis
- •4. Atelectasis due to a bronchoscopically diagnosed:
- •a. foreign body aspiration
- •b. tracheal or bronchial compression by lymph nodes or vessels
- •5. Recurrent atelectasis due to an anatomical airway-abnormality
- •6. RhDNase treatment in the previous 48 hours
- •7. Clinical condition or ventilator settings that are not compatible with nebulising medication (according to the responsible physician)
- •8. Presence of a pneumothorax
- •9. Previous participation in the study
研究者
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Unknown
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