Magnetic Resonance Imaging of the Lung: Oncological Applications
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- assessment of the ability of advanced magnetic resonance imaging techniques to distinguish between immune phenotypes in NSCLC.
研究概览
简要总结
Lung neoplasms are characterized by a complex interaction between tumor cells and a variety of resident and infiltrating host elements, secreted factors, and extracellular matrix proteins, collectively referred to as the microenvironment. Nowadays, in the setting of lung cancer, and in particular non-small cell lung cancer (NSCLC), the evaluation of microenvironment characteristics can only be performed by a pathologist and only on histological material. By combining different MRI parameters, it may be possible to create a specific imaging "signature" for the three different immune phenotypes and thus be able to make a distinction based on MRI examination.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Primary NSCLC of the lung (TNM 8th edition T parameter ≥T1c)
- •Biopsy examination of the primary tumor adequate at least for PDL-1 quantification
- •Staging CT scan with uncertain N parameter and definite M parameter.
排除标准
- •Absolute contraindications to magnetic resonance imaging or the administration of gadolinium-based contrast agents
结局指标
主要结局
assessment of the ability of advanced magnetic resonance imaging techniques to distinguish between immune phenotypes in NSCLC.
时间窗: up to 36 months
次要结局
未报告次要终点
研究者
Chandra Bortolotto
Prof
Fondazione IRCCS Policlinico San Matteo di Pavia