NCT00007033已完成不适用
Study of Magnesium Sulfate in Children With Reduced Bone Density Secondary to Chronic Cholestatic Liver Disease
National Center for Research Resources (NCRR)2 个研究点 分布在 1 个国家目标入组 25 人开始时间: 2000年10月1日最近更新:
适应症
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 25
- 试验地点
- 2
研究概览
简要总结
OBJECTIVES:
I. Determine the role of magnesium deficiency in the pathogenesis of decreased serum vitamin D and reduced bone density in children with chronic cholestatic liver disease.
详细描述
PROTOCOL OUTLINE:
Patients receive magnesium sulfate IV over 1 hour on day 3. Patients then receive oral magnesium gluconate supplementation daily. Treatment with magnesium sulfate repeats once at 3-6 months.
研究设计
- 研究类型
- Interventional
- 主要目的
- Treatment
入排标准
- 年龄范围
- 3 Years 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •PROTOCOL ENTRY CRITERIA:
- •-Disease Characteristics--
- •Diagnosis of liver disease with chronic cholestasis Nonsyndromic intrahepatic cholestasis Alagille's syndrome Extrahepatic biliary atresia
- •Direct bilirubin greater than 2 mg/dL OR Bile acids greater than 20 micromoles/L
- •No hepatic decompensation defined as one or more of the following: Ascites Peripheral edema PT at least 4 seconds longer than control Albumin less than 3 g/dL
- •-Patient Characteristics--
- •Renal: No significant renal disease
- •Cardiovascular: No significant cardiovascular disease
- •Pulmonary: No significant pulmonary disease
排除标准
- 未提供
研究者
研究点 (2)
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