EUCTR2016-001906-41-IE
Active, not recruiting
Phase 1
A randomised control trial of intra articular injectates in knee osteoarthritis: A comparison of corticosteroid (Methylprednisolone Acetate) and NSAID (Ketorolac tromethamine) injections - A randomised control trial of intra articular injectates in knee osteoarthritis
ConditionsKnee osteoarthritis is the condition of interest. Osteoarthritis is a common musculoskeletal complaint, with an underlying pathogenesis related to bio-mechanical stress loading, resulting in initial changes within the articular cartilage, progressing to develop cartilage fibrillationvertical clefts and eventual exposure of subchondral bone and eburnationMedDRA version: 19.0Level: LLTClassification code 10023476Term: Knee osteoarthritisSystem Organ Class: 100000004859Therapeutic area: Diseases [C] - Musculoskeletal Diseases [C05]
Overview
- Phase
- Phase 1
- Intervention
- Not specified
- Conditions
- Knee osteoarthritis is the condition of interest. Osteoarthritis is a common musculoskeletal complaint, with an underlying pathogenesis related to bio-mechanical stress loading, resulting in initial changes within the articular cartilage, progressing to develop cartilage fibrillation
- Sponsor
- Royal College of Surgeons in Ireland
- Status
- Active, not recruiting
- Last Updated
- 9 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Osteoarthritis of the knee, warranting intraarticular injection
- •Are the trial subjects under 18? no
- •Number of subjects for this age range:
- •F.1\.2 Adults (18\-64 years) yes
- •F.1\.2\.1 Number of subjects for this age range 39
- •F.1\.3 Elderly (\>\=65 years) yes
- •F.1\.3\.1 Number of subjects for this age range 39
Exclusion Criteria
- •Patients with a history of renal failure, peptic ulcer disease, or other contraindications to NSAID use
- •Previous gastric bypass surgery
- •Patients with a history of an allergy to NSAIDs
- •Patients under 18
- •Patients unable to give consent to partake in the trial
- •Inability to comprehend nature of the trial
Outcomes
Primary Outcomes
Not specified
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