Adrenal vein sampling as a tool to identify biomarkers that aid the diagnosis of adrenocortical carcinoma - AVS for ACC

Interne Geneeskunde, Endocrinologie0 个研究点目标入组 25 人开始时间: 待定最近更新: 2024年4月9日

适应症

试验速览

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•In order to be eligible to participate in the study group, a subject must meet
•all of the following criteria:
•- Patient age >=18 years
•- High clinical suspicion of adrenocortical carcinoma (ACC), based on clinical
•signs (due to hormonal overproduction) steroid hormone profile and radiological
•features (e.g. tumor size >=4cm, inhomogenous aspect and tumor attenuation of HU
•- Able to provide signed informed consent
•In order to be eligible to participate in the control group, a subject must
•meet all of the following criteria:
•- Patient age >=18 years
•- Routine diagnostic process includes adrenal vein sampling (AVS)
•- No suspicion of malignancy
•- Able to provide signed informed consent
•In case pathological diagnosis from a subject who was initially assessed as
•eligible for the study group does not confirm ACC, this subject will be
•included in the control group and the samples will be analyzed as such.

•Patients are not able to participate if:
•- They have a known allergy to (iodinated) contrast fluid
•- They use vitamin K antagonizing anticoagulants or DOAC*s, except for when on
•the day of the AVS the anticoagulants are already stopped for the following
•adrenal surgery, and in case of using vitamin K antagonizing anticoagulants the
•- The platelet count is below 20
•- Anatomy of the adrenal vein is not suitable for performing the AVS procedure,
•based on the judgement of an experienced interventional radiologist
•- Contraindications for use of Synacthen
•- They have a known hypersensitivity to any of the substances of Synacthen
•- They are pregnant

发起方

Interne Geneeskunde, Endocrinologie