Combined effects of biperiden and acute tryptophan depletion on memory in healthy volunteers: an EEG study
- Conditions
- geen aandoeningnvt
- Registration Number
- NL-OMON32834
- Lead Sponsor
- niversiteit Maastricht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 20
male or female, between 18-35 years of age, healthy (absence of exclusion criteria), normal static binocular activity, body mass index between 18.5 and 30, willingness to sign an informed consent.
history of cardiac, hepatic, renal, pulmonary, neurological, gastrointestinal, haematological or psychiatric illness, are excessive drinking (>20 glasses of alcohol containing beverages a week), pregnancy or lactation, use of medication other than oral contraceptives, use of recreational drugs from 2 weeks before until the end of the experiment, and any sensory or motor deficits which could reasonably be expected to affect test performance. Those volunteers who have a first-degree relative with a psychiatric disorder or a history of a psychiatric disorder will also be excluded.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The main endpoint is the behavioural score on the verbal learning task, the<br /><br>continuous recognition memory task, and the spatial memory task. Secondary, the<br /><br>event-related potentials during those tasks will be analysed. </p><br>
- Secondary Outcome Measures
Name Time Method <p>A further important parameter is the change in behavioural and brain response<br /><br>to the choice reaction time task, since this measures a possible sedative<br /><br>effect of the two manipulations. Finally, we will measure the event-related<br /><br>potential during a novelty oddball task to assess the role of both<br /><br>neurotransmitters in novelty processing.</p><br>