Examination of the Neural Components Underlying the Treatment of Adolescent Major Depression
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 112
- 试验地点
- 1
- 主要终点
- EEG Activity
研究概览
简要总结
The goal of the study is to examine how cognitive behavioral therapy (CBT), a common treatment for adolescent depression, affects brain functioning. Depressed adolescents will complete an initial assessment consisting of an interview, questionnaires, computer tasks, and an EEG recording. EEG (electroencephalography) measures brain activity by recording the electrical activity along the scalp caused by the firing of neurons within the brain. They will then complete 12 sessions of cognitive behavioral therapy, which will be 50 minutes long and held once a week for 12 weeks. Before their third therapy session, participants will complete a computer task while EEG data are recorded. After completing the treatment, the participants will complete a final assessment, which will include questionnaires, computer tasks, and an EEG recording. They will also complete follow-up assessments over the phone 1, 3, and 6 months after completing the treatment.
This study will also include healthy control participants. They will complete an initial assessment consisting of an interview, questionnaires, computer tasks, and an EEG recording. Three weeks later, they will return to complete a behavioral task while EEG data are recorded. Twelve weeks after the initial assessment, they will complete a final assessment, which will include questionnaires, computer tasks, and an EEG recording.
详细描述
The purpose of the study is to examine the impact of individual cognitive behavioral therapy (CBT) for adolescent depression on neural functioning. Specifically, the study will utilize Brent and Poling's (1997) cognitive behavioral therapy (CBT) manual (Cognitive Therapy Treatment Manual for Depressed and Suicidal Youth), and investigators will examine pre- to post- neural activity patterns for children and adolescents who receive individual CBT for depression. Electroencephalography (EEG) techniques will be utilized to assess treatment-related effects on brain activity (i.e., anterior cingulate cortex and dorsolateral prefrontal cortex functioning). Neural activity patterns will also be compared to non-depressed, healthy controls.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 13 Years 至 18 Years（Child, Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •, Major Depressive Disorder Participants:
- •Ages 13-18 years at time of initial assessment
- •Current major depressive disorder (MDD) diagnosed according to the K-SADS Axis I semi-structured interview
- •English as first language or English fluency
排除标准
- •, Major Depressive Disorder Participants:
- •Mania/Hypomania
- •Current anxiety disorders [e.g., Panic Disorder (PD), Generalized Anxiety Disorder (GAD), Obsessive Compulsive Disorder (OCD)]
- •Eating Disorders
- •Substance Abuse/Dependency
- •Conduct Disorder/Antisocial Disorder
- •Psychosis
- •Mental Retardation
- •Organic Brain Syndrome
- •Current Psychotherapy Treatment
- •Medical & neurological illness (head injury, loss of consciousness for more than 5 minutes, seizures)
- •Current use of psychotropic medication for treatment of MDD with the exception of SSRIs (selective serotonin reuptake inhibitors)
- •Active suicidality
- •Inclusion Criteria, Healthy Control Participants:
- •Ages 13-18 years at time of initial assessment
- •English as first language or English fluency
- •Exclusion Criteria, Healthy Control Participants (in addition to the exclusion criteria of the MDD group):
- •Elevated depressive symptoms as assessed in phone screen
研究组 & 干预措施
Cognitive Behavioral Therapy
12 weekly sessions of cognitive behavioral therapy
干预措施: Cognitive Behavioral Therapy (Behavioral)
Healthy Controls
结局指标
主要结局
EEG Activity
时间窗: 12 weeks
EEG and ERP measures collected during resting state and behavioral tasks
次要结局
未报告次要终点
研究者
Randy P. Auerbach
Principal Investigator
Mclean Hospital