To see how Methylene blue drug which is used to increase O2 saturation levels, is helpful in treating Covid 19 patients.

Not yet recruiting

• Conditions: Coronavirus as the cause of diseases classified elsewhere,

• Registration Number: CTRI/2021/04/033142
• Lead Sponsor: DR SMITHA K S

Brief Summary

As Covid pandemic has created a havoc through out the world with alarming morbidity and mortality. There are many treatment modalities at present for covid, one such being treatment with methylene blue. As it is seen that in covid patients there will be hypoxia due to methhemoglobinemia.  Methylene blue is FDA approved drug for the same.Hence , the main purpose of this study is to observe the effects of its treatment in covid patients. Also, this pilot study aims to help in generating a protocol for further randomised controlled studies in treatment of covid patients with Methylene blue.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-03-05
• Last Update Posted: 2021-04-26

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

• 1. Confirmed case of Covid 19 (RT-PCR) 2) Admission to Intensive care unit 3) Sex-Males and Females 4) Age- 18 to 90 years old.
• 5. Need for Oxygen support ( HFNC, NIV) 6) Respiratory rate (RR) between 20 to 30 7) SpO2 between ≤90 to 94 on room air.
• 8. PaO2/FiO2 <200-300 9) Written informed consent.

Exclusion Criteria

• Pregnancy and breastfeeding 2) History of G6PD deficiency 3) Severe renal insufficiency (GFR<30ml/min/1.73m2) 4) Medical records of Cirrhosis 5) Active or Chronic Hepatitis 6) History of allergy to Methylene blue 7) Patients on immunosuppressive agents.
• 8. Patients exposed to aniline dyes and Dapsone.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To observe the effects of Methylene blue treatment in Covid 19 patients.	7 days

Secondary Outcome Measures

Name	Time	Method
To record side effects of Methylene blue treatment in covid 19 patients	30 days

Trial Locations

Locations (1)

Bangalore Medical College and Research Institute; 🇮🇳 Bangalore, KARNATAKA, India

Bangalore Medical College and Research Institute

🇮🇳Bangalore, KARNATAKA, India

Dr Smitha K S

Principal investigator

9886935506

smi9685@gmail.com