Intravenous iron for treatment of Sub-optimal iron stores in Non-Anaemic Patients presenting for major Surgery

The University of Western Australia0 个研究点目标入组 50 人开始时间: 2020年3月6日最近更新: 2020年3月16日

适应症

试验速览

暂无简介。

•1.Non-anaemic adults (haemoglobin >130g/L for males and 120g/L for females) 18 years of age or older with ferritin levels < 100 mcg/L
•2.Planned elective major surgical procedure with anticipated blood loss greater than 500 ml (as listed in Fiona Stanley Hospital Pre-operative Blood Management algorithm).

•1.Anaemia (defined as per WHO criteria including haemoglobin <130g/L for males and 120g/L for females)
•2.Pre-operative evidence of bone marrow insufficiency (i.e. pre-operative haemoglobin <100 g/L, neutrophil count <1.8 x109/L, platelets <100 x109/L) or known haemoglobinopathy
•3.Diagnosed iron overload state (e.g. hereditary haemochromatosis)
•4.Patients unable/unwilling to receive blood products
•5.Pregnancy or lactation
•6.Patients administered parenteral iron or erythropoietin within six weeks prior to surgery or with known allergy/hypersensitivity to Ferric carboxymaltose (Ferinject®)
•7.Chronic renal disease requiring dialysis
•8.Chronic liver disease or screening alanine transaminase (ALT) or aspartate transaminase (AST) above three times the upper limit of normal range
•9.Patients unable to complete 6MWT
•10.Patients unwilling/unable to give consent

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