Comparing the Antiplaque Effects of Novel Titania Nanoparticle Infused Fluoride Varnish vs Conventional Fluoride Varnish in Fixed Orthodontic Patients.

Not Applicable

Recruiting

• Conditions: Dental Plaque Accumulation; Nanoparticles; Fluoride Varnishes

• Registration Number: NCT07180849
• Lead Sponsor: Pakistan Institute of Medical Sciences

Brief Summary

In this study the investigators aimed to explore the antibiofilm effect of fluoride varnish loaded with titania nanoparticles synthesized from moringa oleifera leaves extract vs conventional fluoride varnish in multibracket fixed orthodontic patients.

Detailed Description

Not available

Study Timeline

• Status Verified: 2025-09
• Study First Submitted: 2025-09-12
• Study First Submitted QC: 2025-09-12
• Study First Posted: 2025-09-18
• Last Update Submitted: 2025-09-20
• Last Update Posted: 2025-09-25
• Study Start: 2025-11-01
• Primary Completion: 2027-07
• Study Completion: 2027-12-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
To compare the plaque inhibitory effect of titania nanoparticle infused fluoride varnish and conventional fluoride varnish in fixed orthodontic patients.	6 months	Plaque will be assessed quantitatively by modified plaque index.

Secondary Outcome Measures

Name	Time	Method
To measure plaque bacterial load and pH following application of titania nanoparticle infused and conventional fluoride varnish in fixed orthodontic patients.	6 months	Bacterial colonies will be morphologically identified and counted as Colony Forming Units (CFU) using a colony counting grid.

Trial Locations

Locations (1)

Pakistan Institute of Medical Sciences; 🇵🇰 Islamabad, Pakistan