Study to Gather Information About Proper Dosing and Safety of the Oral FXIa Inhibitor BAY 2433334 in Patients Following a Recent Non Cardioembolic Ischemic Stroke Which Occurs When a Blood Clot Has Formed Somewhere in the Human Body (But Not in the Heart) Travelled to the Brain.
- Conditions
- Acute Non-cardioembolic Ischemic Stroke
- Interventions
- Other: BAY2433334 matching placebo
- Registration Number
- NCT04304508
- Lead Sponsor
- Bayer
- Brief Summary
The purpose of this study is to try to find the best dose of the new drug BAY 2433334 to give to participants and to look at how well BAY 2433334 works on top of antiplatelet therapy in patients following a recent non cardioembolic ischemic stroke which occurs when a blood clot that has not formed in the heart travelled to the brain. BAY 2433334, works by blocking a step of the blood clotting process in our body and thins the blood and is a so called oral FXIa inhibitor.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 1808
-
Participant must be 45 years of age and older at the time of signing the informed consent
-
Non-cardioembolic ischemic stroke with
- persistent signs and symptoms of stroke lasting for ≥ 24 hours OR
- acute brain infarction documented by computed tomography (CT) or MRI AND
- with the intention to be treated with antiplatelet therapy during the study conduct
-
Imaging of brain (CT or MRI) ruling out hemorrhagic stroke or another pathology that could explain symptoms (e.g. brain tumor, abscess, vascular malformation)
-
Severity of index event nearest the time of randomization:
- Part A: minor stroke (defined as National Institutes of Health Stroke Scale (NIHSS) ≤ 7) can be enrolled
- Part B: participants with minor or moderate stroke and NIHSS ≤ 15 can be enrolled. Participants undergoing thrombolysis or endovascular therapy (mechanical thrombectomy) can be enrolled but at the earliest 24 hours after the intervention
-
Randomization within 48 hours after the onset of symptoms of the index event (or after patients were last known to be without symptoms in case of wake-up stroke)
-
Ability to conduct an MRI either before randomization or within 72 hours after randomization
- Prior ischemic stroke within last 30 days of index event
- History of atrial fibrillation or suspicion of cardioembolic source of stroke
- Dysphagia with inability to safely swallow study medication
- Contraindication to perform brain MRI
- Part A only: thrombolysis or endovascular therapy (mechanical thrombectomy) performed for index event
- Active bleeding; known bleeding disorder, history of major bleeding (intracranial, retroperitoneal, intraocular) or clinically significant gastrointestinal bleeding within last 6 months of randomization.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description BAY2433334 high dose BAY2433334 - BAY2433334 matching placebo BAY2433334 matching placebo - BAY2433334 medium dose BAY2433334 - BAY2433334 low dose BAY2433334 -
- Primary Outcome Measures
Name Time Method Efficacy-Number of Participants With Composite of Symptomatic Ischemic Stroke or Covert Brain Infarcts Detected by Magnetic Resonance Imaging (MRI) From baseline up to 26 weeks Ischemic stroke was defined as either of : 1) Rapid onset (or present on awakening) of a new focal neurological deficit with clinical (\>24 hours symptoms/signs) or imaging evidence of infarction that was not attributable to a non-ischemic cause; 2) Acute worsening of an existing focal neurological deficit that was judged to be attributable to a new infarction or extension of the previous infarction in the same vascular territory, based on persisting symptoms/signs or imaging evidence of infarction and no evidence of a non-ischemic etiology. If imaging was inconclusive, persistent symptoms/signs must be significant (worsening of NIHSS score of 4 or more) and sustained (duration of ≥24 hours or until death). Covert brain infarcts were defined as incident infarcts detected by serial MRI in the absence of an adjudicated stroke consistent with the location of the infarct. MRI criteria for brain infarction were available in the MRI procedures manual.
Safety-Number of Participants With Composite of International Society on Thrombosis and Hemostasis (ISTH) Major Bleeding and Clinically Relevant Non-major (CRNM) Bleeding From baseline up to 52 weeks ISTH Major Bleeding criteria: 1. Fatal bleeding, and/or 2. Symptomatic bleeding in a critical area or organ (intracranial, intraocular, intraspinal, pericardial, retroperitoneal, intraarticular, or intramuscular with compartment syndrome), and/or 3. Clinically overt bleeding associated with a recent decrease in the hemoglobin level of ≥ 2 g/dL (20 g/L; 1.24 mmol/L) compared to the most recent hemoglobin value available before the event, and/or 4. Clinically overt bleeding leading to transfusion of 2 or more units of packed red blood cells or whole blood. ISTH Clinically Relevant Non-Major Bleeding is considered any sign or symptom of hemorrhage that does not fit the criteria for the ISTH definition of major bleeding, but does meet at least one of the following criteria 1. requiring medical intervention by a healthcare professional. 2. leading to hospitalization or increased level of care. 3. prompting a face to face (i.e. not just a telephone or electronic communication) evaluation.
- Secondary Outcome Measures
Name Time Method Efficacy-Number of Participants With All-cause Mortality From baseline up to 52 weeks Efficacy-Number of Participants With Composite of Symptomatic Ischemic Stroke and Covert Brain Infarcts Detected by MRI, Cardiovascular (CV) Death, Myocardial Infarction (MI) and Systemic Embolism. From baseline up to 26 weeks CV death included death due to stroke, MI, heart failure or cardiogenic shock, sudden death or any other death due to other cardiovascular causes. Death due to non-traumatic hemorrhage was included. Acute MI was used when there was evidence of myocardial necrosis in a clinical setting consistent with acute myocardial ischemia. According to MI Universal Definition from 2018 the diagnosis of MI required the combination of: 1) Presence of acute myocardial injury, and 2) Evidence of acute myocardial ischemia derived from the clinical presentation, electrocardiographic changes, or the results of myocardial or coronary artery imaging, or in case of post-mortem pathological findings irrespective of biomarker values. Systemic embolism was defined as abrupt vascular insufficiency associated with clinical or radiological evidence of arterial occlusion in the absence of other likely mechanisms (this did not include thromboembolism of the pulmonary vasculature or venous thrombosis).
Efficacy-Number of Participants With Covert Brain Infarcts Detected by MRI From baseline up to 26 weeks Definition of covert brain infarcts can be referred to first Primary endpoint.
Safety-Number of Participants With ISTH Major Bleeding From baseline up to 52 weeks Definition of ISTH major bleeding can be referred to second Primary endpoint.
Efficacy-Number of Participants With Symptomatic Ischemic Stroke, CV Death, MI From baseline up to 52 weeks Definition of symptomatic ischemic stroke can be referred to first Primary endpoint. Definition of CV death and MI can be referred to first Second endpoint.
Efficacy-Number of Participants With Symptomatic Ischemic and Hemorrhagic Stroke From baseline up to 52 weeks Definition of symptomatic ischemic can be referred to fourth secondary endpoint. Hemorrhagic stroke was defined as an acute, atraumatic extravasation of blood into the brain parenchyma, intraventricular or subarachnoid space with associated neurological symptoms. This did not include microbleeds or hemorrhagic transformation of an ischemic stroke.
Efficacy-Number of Participants With Symptomatic Ischemic Stroke From baseline up to 52 weeks Definition of symptomatic ischemic stroke can be referred to first Primary endpoint.
Safety-Number of Participants With Intracerebral Hemorrhage (Non-traumatic) From baseline up to 52 weeks Non-traumatic intracerebral hemorrhage was defined as a hemorrhagic stroke on the "recurrent stroke" CRF page that is in addition classified as a bleeding with bleeding site intracranial (-subarachnoid, -intraparenchymal \[excluding microbleeds\], or -intraventricular) and spontaneous causality of bleeding, excluding all symptomatic and hemorrhagic transformation (defined by the PT "hemorrhagic transformation").
Safety-Number of Participants With ISTH CRNM Bleeding From baseline up to 52 weeks Definition of ISTH CRNM bleeding can be referred to second Primary endpoint.
Safety-Number of Participants With ISTH Minor Bleeding From baseline up to 52 weeks All other overt bleeding episodes not meeting the above criteria for ISTH major or CRNM bleeding were classified as minor bleeding (e.g. bleeding from a minor wound that does not prompt a face-to-face evaluation for a physical examination or laboratory testing).
Efficacy-Number of Participants With Disabling Stroke (mRS≥4) From baseline up to 52 weeks Modified ranking score (mRS): 0-No symptoms at all; 1-No significant disability despite symptoms; despite symptoms, able to carry out all usual duties and activities; 2-Slight disability; unable to carry out all previous activities but able to look after own affairs without assistance; 3-Moderate disability; requiring some help, but able to walk without assistance; 4-Moderately severe disability; unable to walk without assistance and unable to attend to own bodily needs without assistance; 5-Severe disability; bedridden, incontinent and requiring constant nursing care and attention; 6-Death.
Safety-Number of Participants With All Bleeding From baseline up to 52 weeks All bleeding events occurred from first intake of study intervention until 2 days after the last intake of study intervention.
Trial Locations
- Locations (197)
Guilford Neurologic Associates
🇺🇸Greensboro, North Carolina, United States
Fiona Stanley Hospital
🇦🇺Murdoch, Western Australia, Australia
John Hunter Hospital
🇦🇺New Lambton, New South Wales, Australia
Royal North Shore Hospital
🇦🇺Sydney, New South Wales, Australia
Sunshine Coast University Hospital
🇦🇺Birtinya, Queensland, Australia
Konventhospital Barmherzige Brüder Linz
🇦🇹Linz, Oberösterreich, Austria
Krankenhaus der Barmherzigen Brüder Eisenstadt
🇦🇹Eisenstadt, Burgenland, Austria
CHC MontLégia
🇧🇪Liege, Liège, Belgium
AZ Klina / Neurology
🇧🇪Brasschaat, Belgium
HUS, Meilahden sairaala
🇫🇮Helsinki, Finland
Centre Hospitalier Universitaire - Le Kremlin Bicêtre
🇫🇷Le Kremlin-bicetre, France
Centre Hospitalier - Le Mans
🇫🇷Le Mans, France
Hopital Central - Nancy
🇫🇷Nancy, France
Centre hospitalier Sainte Anne
🇫🇷PARIS cedex 14, France
Universitätsklinikum der Johann Wolfgang Goethe Universität
🇩🇪Frankfurt, Hessen, Germany
Klinikum Frankfurt Höchst GmbH
🇩🇪Frankfurt, Hessen, Germany
Medizinische Hochschule Hannover (MHH)
🇩🇪Hannover, Niedersachsen, Germany
Heinrich-Heine-Universität Düsseldorf
🇩🇪Düsseldorf, Nordrhein-Westfalen, Germany
Universitätsklinikum Leipzig AöR
🇩🇪Leipzig, Sachsen, Germany
Flor Ferenc Korhaz
🇭🇺Kistarcsa, Hungary
AUSL della Romagna
🇮🇹Forlì Cesena, Emilia-Romagna, Italy
AUSL-IRCCS di Reggio Emilia
🇮🇹Reggio Emilia, Emilia-Romagna, Italy
A.O. San Camillo-Forlanini
🇮🇹Roma, Lazio, Italy
Ospedale San Raffaele s.r.l.
🇮🇹Milano, Lombardia, Italy
Samodzielny Publiczny Szpital Kliniczny nr 4
🇵🇱Lublin, Poland
Luz Saude | Hospital Beatriz Angelo - Centro de Investigacao Clinica
🇵🇹Loures, Lisboa, Portugal
City Clinical Hospital #3
🇷🇺Chelyabinsk, Russian Federation
Fakultna nemocnica AGEL Skalica, a.s.
🇸🇰Skalica, Slovakia
Svet zdravia, a.s. Nemocnica s poliklinikou Spisska Nova Ves
🇸🇰Spisska Nova Ves, Slovakia
Vseobecna nemocnica s poliklinikou Levoca, a.s.
🇸🇰Levoca, Slovakia
Fakultna nemocnica Trnava
🇸🇰Trnava, Slovakia
Vseobecna nemocnica v Ziari nad Hronom
🇸🇰Ziar nad Hronom, Slovakia
Hospital de la Santa Creu i Sant Pau | Neurology Department - Stroke, No-Cardioembolic-Tia
🇪🇸Barcelona, Spain
Huashan Hospital, Fudan University
🇨🇳Shanghai, China
Nemocnice na Homolce - Neurology Department
🇨🇿Praha 5-Motol, Czechia
Hôpital de la Pitié-Salpétrière
🇫🇷Paris, France
Hospital Rey Juan Carlos
🇪🇸Móstoles, Madrid, Spain
A.O. di Perugia
🇮🇹Perugia, Umbria, Italy
Minneapolis Clinic of Neurology, Ltd.
🇺🇸Golden Valley, Minnesota, United States
Universitätsspital Basel
🇨🇭Basel, Basel-Stadt, Switzerland
Univ.of South Florida College of Medicine
🇺🇸Tampa, Florida, United States
St. Luke's Hospital of Kansas City
🇺🇸Kansas City, Missouri, United States
Gold Coast University Hospital
🇦🇺Southport, Queensland, Australia
Liverpool Hospital
🇦🇺Liverpool, New South Wales, Australia
University of Pittsburgh Medical Center Hamot
🇺🇸Erie, Pennsylvania, United States
Grampians Health Ballarat
🇦🇺Ballarat, Victoria, Australia
Royal Adelaide Hospital
🇦🇺Adelaide, South Australia, Australia
The Alfred Hospital
🇦🇺Prahran, Victoria, Australia
Royal Melbourne Hospital
🇦🇺Parkville, Victoria, Australia
Eastern Clinical Research Unit - Box Hill
🇦🇺Box Hill, Victoria, Australia
Christian-Doppler-Klinik
🇦🇹Salzburg, Austria
Klinik Favoriten - Sozialmedizinisches Zentrum Süd
🇦🇹Wien, Austria
Universitätsklinikum AKH Wien
🇦🇹Wien, Austria
Krankenhaus der Barmherzigen Brüder
🇦🇹Wien, Austria
Jessa Ziekenhuis
🇧🇪Hasselt, Limburg, Belgium
UZ Brussel
🇧🇪Brussel, Belgium
UZ Leuven Gasthuisberg
🇧🇪Leuven, Belgium
Kust, Ommeland en Meetjesland (KOM) Network | AZ Damiaan - Neurology Department
🇧🇪Oostende, Belgium
AZ Delta / Neurology
🇧🇪Roeselare, Belgium
Clinique de l'Europe
🇧🇪Uccle, Belgium
MHAT Haskovo
🇧🇬Haskovo, Bulgaria
UMHAT Dr. Georgi Stranski
🇧🇬Pleven, Bulgaria
MHAT Sveti Pantaleymon - Plovdiv
🇧🇬Plovdiv, Bulgaria
First Multiprofile Hospital for Active Treatment Sofia EAD
🇧🇬Sofia, Bulgaria
UMHAT Kanev AD
🇧🇬Ruse, Bulgaria
Acibadem City Clinic Multiprofile Hospital for Active Treatm
🇧🇬Sofia, Bulgaria
MHAT National Cardiology Hospital EAD
🇧🇬Sofia, Bulgaria
UMHATEM N. I. Pirogov EAD
🇧🇬Sofia, Bulgaria
UMHAT "Sveta Anna"-Sofia
🇧🇬Sofia, Bulgaria
Daqing Oilfield General Hospital
🇨🇳Daqing, Heilongjiang, China
MHAT Sveta Marina EAD
🇧🇬Varna, Bulgaria
Baogang hospital
🇨🇳Baotou, Inner Mongolia, China
Nanjing First Hospital
🇨🇳Nanjing, Jiangsu, China
Zhongda Hospital Southeast University
🇨🇳Nanjing, Jiangsu, China
People's Hospital of Deyang City
🇨🇳Deyang, Sichuan, China
The First Hospital of Jilin University
🇨🇳Changchun, Jilin, China
Fakultni Nemocnice Hradec Kralove
🇨🇿Hradec Kralove, Czechia
Hospital Jihlava - Nemocnice Jihlava
🇨🇿Jihlava, Czechia
Fakultni nemocnice u sv. Anny
🇨🇿Brno, Czechia
Tianjin Huanhu Hospital
🇨🇳Tianjin, China
Fakultni nemocnice Ostrava
🇨🇿Ostrava-Poruba, Czechia
Nemocnice Ceske Budejovice, a.s. Department of kardiologie
🇨🇿Ceske Budejovice, Czechia
Vitkovicka nemocnice a.s.
🇨🇿Ostrava Vitkovice, Czechia
Fakultni nemocnice Kralovske Vinohrady
🇨🇿Praha 10, Czechia
Nemocnice Pardubickeho kraje, a.s., Pardubicka nemocnice
🇨🇿Pardubice, Czechia
Bispebjerg Hospital
🇩🇰Copenhagen, Denmark
Aalborg Universitetshospital -Neurology
🇩🇰Aalborg, Denmark
Aarhus Universitetshospital, Skejby
🇩🇰Aarhus N, Denmark
Rigshospitalet Glostrup
🇩🇰Glostrup, Denmark
Herlev Hospital - Neurology Dept.
🇩🇰Herlev, Denmark
Regionshospitalet Gødstrup
🇩🇰Herning, Denmark
Nordsjælland Hospital Hillerød
🇩🇰Hillerød, Denmark
Turun yliopistollinen keskussairaala
🇫🇮Turku, Finland
Sygehus Lillebaelt | Kolding Sygehus - Medicinske Sygdomme
🇩🇰Kolding, Denmark
Itä-Suomen yliopisto
🇫🇮Kuopio, Finland
Hopital Jean Minjoz
🇫🇷Besancon, France
Hôpital Pellegrin - Bordeaux
🇫🇷Bordeaux, France
Hôpital B - Lille
🇫🇷Lille, France
Hôpital Lariboisière - Paris
🇫🇷Paris, France
Hôpital Pontchaillou
🇫🇷Rennes Cedex, France
Hôpital Purpan - Toulouse
🇫🇷Toulouse, France
Universitätsklinikum Heidelberg
🇩🇪Heidelberg, Baden-Württemberg, Germany
Universitätsklinikum Ulm
🇩🇪Ulm, Baden-Württemberg, Germany
Eberhard-Karls-Universität Tübingen
🇩🇪Tübingen, Baden-Württemberg, Germany
Rhön-Klinikum Campus Bad Neustadt
🇩🇪Bad Neustadt, Bayern, Germany
Alfried Krupp Krankenhaus Rüttenscheid /Neurologie
🇩🇪Essen, Nordrhein-Westfalen, Germany
Klinikum Altenburger Land GmbH
🇩🇪Altenburg, Thüringen, Germany
Debreceni Egyetem Klinikai Kozpont
🇭🇺Debrecen, Hungary
Eszak-Pesti Centrumkorhaz-Honvedkorhaz
🇭🇺Budapest, Hungary
Pecsi Tudomanyegyetem Klinikai Kozpont
🇭🇺Pecs, Hungary
SZTE ÁOK Szent Györgyi Albert Klinikai Kozpont
🇭🇺Szeged, Hungary
Zala Megyei Szent Rafael Korhaz
🇭🇺Zalaegerszeg, Hungary
AUSL di Bologna
🇮🇹Bologna, Emilia-Romagna, Italy
Fondazione Istituto Neurologico Nazionale Casimiro Mondino
🇮🇹Pavia, Lombardia, Italy
A.O.U. Ospedali Riuniti "Umberto I - G.M.Lancisi - G.Salesi"
🇮🇹Ancona, Marche, Italy
Kokura Memorial Hospital
🇯🇵Kitakyushu, Fukuoka, Japan
A.O.U. Senese
🇮🇹Siena, Toscana, Italy
Nagoya Ekisaikai Hospital
🇯🇵Nagoya, Aichi, Japan
Southern Tohoku Medical Clinic
🇯🇵Koriyama, Fukushima, Japan
Hyogo Prefectural Harima-Himeji General Medical Center
🇯🇵Himeji, Hyogo, Japan
St.Mary's Hospital
🇯🇵Kurume, Fukuoka, Japan
Hakodate Shintoshi Hospital
🇯🇵Hakodate, Hokkaido, Japan
Kobe City Medical Center General Hospital
🇯🇵Kobe, Hyogo, Japan
JA Toride Medical Center
🇯🇵Toride, Ibaraki, Japan
Nozaki Tokushukai Hospital
🇯🇵Daito, Osaka, Japan
Saiseikai Fukuoka General Hospital
🇯🇵Fukuoka, Japan
Shonan Kamakura General Hospital
🇯🇵Kamakura, Kanagawa, Japan
Kyoto Okamoto Memorial Hospital
🇯🇵Kusegun, Kyoto, Japan
Kyorin University Hospital
🇯🇵Mitaka, Tokyo, Japan
Uji-Tokushukai Medical Center
🇯🇵Uji, Kyoto, Japan
National Hospital Organization Kyushu Medical Center
🇯🇵Fukuoka, Japan
Hiroshima City Hiroshima Citizens Hospital
🇯🇵Hiroshima, Japan
Chikamori Hospital
🇯🇵Kochi, Japan
Gifu Prefectural General Medical Center
🇯🇵Gifu, Japan
Saiseikai Kumamoto Hospital
🇯🇵Kumamoto, Japan
Japanese Red Cross Kumamoto Hospital
🇯🇵Kumamoto, Japan
Ijinkai Takeda General Hospital
🇯🇵Kyoto, Japan
Academisch Medisch Centrum (AMC)
🇳🇱Amsterdam, Netherlands
Zuyderland Medisch Centrum
🇳🇱Heerlen, Netherlands
Nagano Municipal Hospital
🇯🇵Nagano, Japan
St. Antonius Ziekenhuis
🇳🇱Nieuwegein, Netherlands
Isala
🇳🇱Zwolle, Netherlands
Copernicus PL, M.Kopernik Hospital
🇵🇱Gdansk, Poland
Samodzielny Publiczny Specjalistyczny Szpital Zachodni
🇵🇱Grodzisk Mazowiecki, Poland
Szpital Uniwersytecki w Krakowie
🇵🇱Krakow, Poland
Gornoslaskie CM im. Prof. Leszka Gieca SUM w Katowicach
🇵🇱Katowice, Poland
Wojskowy Instytut Medyczny
🇵🇱Warszawa, Poland
Mazowiecki Szpital Specjalistyczny im. dr. Jozefa Psarskiego
🇵🇱Ostroleka, Poland
Hospital Garcia de Orta | Research Department
🇵🇹Almada, Setúbal, Portugal
ULSM - Hospital Pedro Hispano
🇵🇹Matosinhos, Porto, Portugal
CHUC - Hospitais da U. Coimbra - Servico de Neurologia
🇵🇹Coimbra, Portugal
Hospital da Luz - Lisboa
🇵🇹Lisboa, Portugal
CHLO - Hospital Egas Moniz
🇵🇹Lisboa, Portugal
CHULN - Hospital Santa Maria
🇵🇹Lisboa, Portugal
Sci-Res. Institute of Complex Cardiovascular Disorders
🇷🇺Kemerovo, Russian Federation
CHUSJ - Hospital Sao Joao
🇵🇹Porto, Portugal
Regional Clinical Hospital #1 n.a. prof. S.V. Ochapovsky
🇷🇺Krasnodar, Russian Federation
Tomsk Regional Clinical Hospital
🇷🇺Tomsk, Russian Federation
City clinical hospital #40 Sestroretsk
🇷🇺Sestroretsk, Russian Federation
Railway clinical hospital on the station Novosibirsk-Glavniy
🇷🇺Novosibirsk, Russian Federation
Clinical Inter-District Hospital of Vsevolozhsk
🇷🇺Vsevolozhsk, Russian Federation
Univerzitna nemocnica Bratislava, Nemocnica Stare Mesto
🇸🇰Bratislava, Slovakia
Sverdlovsk Regional Clinical Hospital #1
🇷🇺Yekaterinburg, Russian Federation
Dolnooravska nemocnica s poliklinikou L. Nadasi Jegeho
🇸🇰Dolny Kubin, Slovakia
Liptovska nemocnica s poliklinikou MUDr. Ivana Stodolu
🇸🇰Liptovsky Mikulas, Slovakia
Svet zdravia, a. s. Vseobecna nemocnica Rimavska Sobota
🇸🇰Rimavska Sobota, Slovakia
Hospital Clínico Universitario de Santiago de Compostela
🇪🇸Santiago de Compostela, A Coruña, Spain
Hospital de la Mútua de Terrassa
🇪🇸Terrassa, Barcelona, Spain
Hospital Universitari Germans Trias i Pujol
🇪🇸Badalona, Barcelona, Spain
Hospital del Mar
🇪🇸Barcelona, Spain
Ciutat Sanitaria i Universitaria de la Vall d'Hebron
🇪🇸Barcelona, Spain
Complejo Hospitalario Universitario de Albacete | Hospital General Universitario - Neurology Department, Stroke Unit
🇪🇸Albacete, Spain
Hospital Universitario de la Princesa
🇪🇸Madrid, Spain
Hospital Universitario Arnau de Vilanova de Lleida
🇪🇸Lleida, Spain
La Fe University and Polytechnic Hospital | Neurology Service - Vascular Unit
🇪🇸Valencia, Spain
Hospital Universitario Virgen del Rocío
🇪🇸Sevilla, Spain
Skånes Universitetssjukhus
🇸🇪Lund, Sweden
Hospital Universitario Clinico de Valladolid | Neurology Department
🇪🇸Valladolid, Spain
Norrlands Universitetssjukhus, Umeå
🇸🇪Umeå, Sweden
Spitalzentrum Biel
🇨🇭Biel, Bern, Switzerland
Kantonsspital Baden
🇨🇭Baden, Switzerland
Kantonsspital St. Gallen
🇨🇭St. Gallen, Sankt Gallen, Switzerland
Inselspital Universitätsspital Bern
🇨🇭Bern, Switzerland
Danderyds sjukhus
🇸🇪Stockholm, Sweden
Ospedale regionale di Lugano
🇨🇭Lugano, Switzerland
Arrowe Park Hospital
🇬🇧Wirral, Merseyside, United Kingdom
Countess of Chester Hospital
🇬🇧Chester, Cheshire, United Kingdom
Royal Victoria Infirmary
🇬🇧Newcastle Upon Tyne, Tyne And Wear, United Kingdom
Glasgow Royal Infirmary | Glasgow Clinical Research Facility
🇬🇧Glasgow, United Kingdom
St George's Hospital
🇬🇧London, United Kingdom
Addenbrookes Hospital
🇬🇧Cambridge, United Kingdom
Queen Elizabeth University Hospital
🇬🇧Glasgow, United Kingdom
Hospital Universitario Ramon y Cajal | Neurology Department - Stroke, No-Cardioembolic-Tia
🇪🇸Madrid, Spain
Hospital Clinico Universitario San Carlos | Neurologia
🇪🇸Madrid, Spain
University Hospitals Coventry and Warwickshire NHS Trust
🇬🇧Coventry, United Kingdom
Medizinische Universität Innsbruck
🇦🇹Innsbruck, Tirol, Austria
Charing Cross Hospital
🇬🇧London, United Kingdom