Role of acetazolamide and hydrochlorothiazide followed by furosemide in treating edema
Phase 3
- Conditions
- Refractory edema in nephrotic syndrome.Incl.: congenital nephrotic syndrome, lipoid nephrosis
- Registration Number
- IRCT2014081518798N1
- Lead Sponsor
- Shiraz Nephrourology Research Center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 20
Inclusion Criteria
Inclusion Criteria:
1. Having refractory edema due to nephrotic syndrome
2. Normal BUN and creatinine
3. Being able to come for weekly visit
4. More than 18 years of age
5. Signing the informed consent form
Exclusion Criteria
1. Hypokalemia
2. Pregnancy
3. Renal transplant
4. Present malignancy
5. Severe acidosis
6. Using NSAIDs
7. Having another causes of edema including liver cirrhosis, heart failure
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Weight. Timepoint: 3 weeks after the starting the drugs. Method of measurement: Using a scale.
- Secondary Outcome Measures
Name Time Method Blood Urea Nitrogen. Timepoint: 3 weeks after starting the drugs. Method of measurement: By labratory.;Serum Creatinine. Timepoint: 3 weeks after starting the drugs. Method of measurement: By labratory.;Serum Sodium. Timepoint: 3 weeks after starting the drugs. Method of measurement: By labratory.;Serum Potassium. Timepoint: 3 weeks after starting the drugs. Method of measurement: By labratory.;Serum Triglycerides. Timepoint: 3 weeks after starting the drugs. Method of measurement: By labratory.;Serum Cholesterol. Timepoint: 3 weeks after starting the drugs. Method of measurement: By labratory.