Analysis of an association between dry eye and ocular surface and intestinlal microbiome

Not Applicable

Recruiting

• Conditions: Chronic graft-versus-host disease (GVHD)-related dry eye disease after hematopoietic stem cell transplantation

• Registration Number: JPRN-UMIN000035618
• Lead Sponsor: Keio University School of Medicine

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-01-22
• Study Completion: 2020-03-15
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

Not provided

Exclusion Criteria

1) No written informed consent 2) No other autoimmune disease 3) No allergic conjunctivitis, ocular surface infectious disease, nor contact lens wearer 4) No dry eye disease before hematopietic stem cell transplantation

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Characterization of microbiota for chronic GVHD-related dry eye disease compared with the controls.

Secondary Outcome Measures

Name	Time	Method
Functional expectation of ocular surface and intestinal microbiome depending on the severity of chronic GVHD-related dry eye disease.