ext generation urine diagnostics and monitoring- urine FACS in urinary tractinfectio

• Conditions: N39.0; Z94.0; Urinary tract infection, site not specified; Kidney transplant status

• Registration Number: DRKS00025922
• Lead Sponsor: Charité Campus Charité Mitte

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2021-07-21
• Study Completion: 2023-09-30
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

Kidney transplantation, follow up clinic visit

Exclusion Criteria

Acute rejection, Anuria, Nephrostomy, ileal conduit.

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Main hypothesis: Microbiome and cell signature differ in kidney transplant patients with and without urinary tract infection. Analysis of differences is feasible by urine FACS.

Secondary Outcome Measures

Name	Time	Method
Other Hypotheses: <br>-Urinays cell signatures and microbiome are significantly correlated<br>-Urinary immune cell populations hold a predictive value for the development of UTI or relapse of UTI<br>-Urinary cell signatures differ depending on bacteria colonization<br>-Urinary cell populations differ in patients with asymptomatic bacteriuria and UTI<br>-Urinary cell signatures and transplant function are significantly correlates during / after UTI