Vitamin D Deficiency: Bone Loss and Vascular Dysfunction
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- to determine if differences exist in vascular compliance and carotid artery intima media thickness between individuals with normal and low vitamin D levels
研究概览
简要总结
To learn if there is a connection between low vitamin D level and hardening of the arteries.
详细描述
Osteoporosis and vascular disease are two of the most common disorders affecting postmenopausal women. A potential association, beyond aging, has long been speculated. Our previous study revealed evidence of loss of vascular compliance in postmenopausal women with lower bone density, suggesting women with lower bone density had "stiffer" blood vessels. This proposal further investigates that association and a potential role of vitamin D deficiency as a possible common link between both bone loss and "hardening of the arteries".
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Factorial
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 50 Years 至 90 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Females ages 50-70 with ability to give informed consent
- •One year past last menstrual period
- •20 women with Vitamin D levels < 15 mg/ml
- •20 women with Vitamin D levels > 30 mg/ml
排除标准
- •women receiving hormone replacement therapy
- •women receiving medication known to effect vascular compliance, including anti-hypertension medications
- •subjects receiving therapy for osteoporosis
- •hyperthyroidism
- •untreated hypothyroidism
- •history of metabolic bone disease
- •current or previous use of medications known to accelerate bone loss
- •chronic liver disease
- •chronic renal disease
- •diabetes mellitus
- •obesity, BMI > 24
结局指标
主要结局
to determine if differences exist in vascular compliance and carotid artery intima media thickness between individuals with normal and low vitamin D levels
to evaluate correlation of markers of vascular disease and boen disease between individuals with normal and low vitamin D
to quantify the effect of Vitamin D replacement on vascular compliance and markers of bone loss and vascular disease.
次要结局
- Vitamin D at the end of 3 months of supplementation.