Rectal Indomethacin Versus Intraperitoneal Lidocaine for Analgesia After Laparoscopic Cholecystectomy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- VAS scores postoperative
研究概览
简要总结
Hospitals, Qena, Egypt in period between May 2020 to May 2021.eighty patients was scheduled to elective laparoscopic cholecystectomy , divided Into two groups randomly using closed envelop method. Group IP lidocaine(40 patients ) received 200 ml saline containing 200 mg 2%lidocaine immediately after abdominal cO2 insufflation( pneumoperitoneum) the surgeon sprayed the total solution on the upper surface of the liver under the right subdiaphragmatic space, left subdiaphragmatic space and around the cholecystectomy site , all patients were maintained in trendelenberg position.
At the end of the laparoscopic procedure, group indomethacin (40 patients) recived two 100 mg indomethacin rectal suppositories 2 hours prior to surgery
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •.ASA physical status 1-2 patients.
- •18-60 years old .
排除标准
- •using or allergic to nonsteroidal anti inflammatory drugs (NSAIDs) or aspirin .
- •history of serious hepatic disease.
- •renal or gastrointestinal disease.
- •bleeding disorder.
- •body mass index BMI <18 or ˃30 m2/kg.
- •history of abdominal surgery or chronic pain disorder other than gallbladder.
- •disease or allergy to lidocaine.
研究组 & 干预措施
indomethacin group
group indomethacin (40 patients) recived two 100 mg indomethacin rectal suppositories 2 hours prior to surgery
干预措施: Indomethacin suppository (Drug)
intraperitoneal lidocaine
200 ml saline containing 200 mg 2%lidocaine immediately after abdominal cO2 insufflation( pneumoperitoneum) the surgeon sprayed the total solution on the upper surface of the liver under the right subdiaphragmatic space, left subdiaphragmatic space and around the cholecystectomy site , all patients were maintained in trendelenberg position
干预措施: Lidocaine 2% Injectable Solution (Drug)
结局指标
主要结局
VAS scores postoperative
时间窗: 24 hours posoperative
a standard 10-cm VAS was used, where one end of the scale represented no pain (0 cm), and the other end the most severe pain imaginable (10 cm), the distance in centimeters being taken as the pain score
postoperative opoiods analgesics requirements
时间窗: 24 hours postoperative
we used (iv pethidine )whenever the patient complained of pain. IV pethidine injection 25-50 mg was given as rescue analgesic whenever the patient experienced pain ≥ to 5 VAS
次要结局
- Pain starting time after surgery and Pethidine required first time.(24 hours postoperative)
研究者
Gad Sayed Gad
assisstant professor
South Valley University