Efficacy of Different Anesthesia Methods in Transbronchial Biopsy

Completed

• Conditions: Biopsy; Respiratory Diseases; Anesthesia
• Interventions: Procedure: general anesthesia

• Registration Number: NCT06454513
• Lead Sponsor: Sichuan Provincial People's Hospital

Brief Summary

This study investigates the efficacy of different anesthesia methods (general anesthesia with laryngeal mask airway and local nebulized anesthesia) for transbronchial biopsy using an electronic bronchoscope. The study retrospectively analyzed cases of transbronchial biopsy performed at the Respiratory Endoscopy Center of Sichuan Provincial People's Hospital from June 5, 2020, to June 5, 2024. Data collected included age, gender, primary diagnosis, anesthesia method, biopsy method, operation time (excluding general anesthesia and laryngeal mask airway placement time), lesion location and size, pathological results, and follow-up status.

Detailed Description

General anesthesia and local anesthesia are the primary anesthesia methods for interventional respiratory endoscopy. While general anesthesia offers greater comfort, it carries anesthesia-related risks. Local anesthesia, on the other hand, provides a relatively low surgical risk and cost-effectiveness. However, there is limited research on whether its diagnostic value is inferior to that of general anesthesia.This study investigates the efficacy of the two anesthesia methods (general anesthesia with laryngeal mask airway and local nebulized anesthesia) for transbronchial biopsy. The study retrospectively analyzed cases of transbronchial biopsy performed at the Respiratory Endoscopy Center of Sichuan Provincial People's Hospital from June 5, 2020, to June 5, 2024. Data collected included age, gender, primary diagnosis, anesthesia method, biopsy method(forcep/cryobiopsy), operation time (excluding general anesthesia and laryngeal mask airway placement time), lesion location and size, pathological results, and follow-up status(pneumothorax、hemorrhage).

Study Timeline

• Study Start: 2020-06-01
• Status Verified: 2024-06
• Primary Completion: 2024-06-01
• Study Completion: 2024-06-01
• Study First Submitted: 2024-06-06
• Study First Submitted QC: 2024-06-11
• Last Update Submitted: 2024-06-11
• Study First Posted: 2024-06-12
• Last Update Posted: 2024-06-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 800

Inclusion Criteria

• Completed Transbronchial Biopsy；the platelets count and PT, APTT tests were normal, normal ECG, Anesthesiologist evaluation was needed in General anesthesia group.

Exclusion Criteria

• patients with contraindication of bronchoscopy (such as respiratory failure and acute cardio-cerebrovascular events), and women who were pregnant.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
General anesthesia	general anesthesia	There all cases in this group where the surgical anesthesia method is general anesthesia

Primary Outcome Measures

Name	Time	Method
Diagnostic efficacy	baseline	The diagnostic positivity rate(%) of transbronchial biopsy under different anesthesia methods between two groups

Secondary Outcome Measures

Name	Time	Method
Clinical information	baseline	age（year）, gender(male/female), primary diagnosis(lung cancer/pneumonia or other)
lesion location (left/right/other)	baseline	Clinical information
lesion size (mm)	baseline	Clinical information
Postoperative complications (hemorrhage or pneumothorax）	baseline	Clinical information
Operation time	intraoperative	Clinical information

Trial Locations

Locations (1)

Sichuan Provincial People's Hospital; 🇨🇳 Chengdu, Sichuan, China