Implantation of Markers for the Radiotherapy of Lung Cancer Patients

Virginia Commonwealth University1 site in 1 country6 target enrollmentFebruary 2008

ConditionsLung Cancer

Overview

Phase: Phase 1
Intervention: Not specified
Conditions: Lung Cancer
Sponsor: Virginia Commonwealth University
Enrollment: 6
Locations: 1
Primary Endpoint: Positional reliability of markers
Status: Terminated
Last Updated: 12 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

This clinical trial studies imaging markers in planning radiation therapy in patients with lung cancer. Implanting markers in the tumor that can be seen using imaging procedures during radiation therapy may allow x-rays to be sent directly to the tumor and cause less damage to normal tissue.

Detailed Description

OBJECTIVES: * To acquire experience in the marker implantation process for mediastinal lymph nodes and primary lung tumors in patients with stage I-IIIB non-small cell lung cancer. * To characterize the potential side effects involved in the use of markers in these patients. * To analyze the positional stability of lung markers in these patients over a radiotherapy series. * To acquire experience in the use of markers for treatment planning and radiotherapy in these patients. OUTLINE: Patients undergo implantation of ≥ 1 small radio-opaque Visicoil™ marker into or close to the primary lesion and affected lymph nodes by bronchoscopy. Patients then undergo x-rays to document marker location, detect potentially dropped markers, and diagnose operation-related side effects (i.e., pneumothorax). After marker implantation, patients undergo stereotactic or conventionally fractionated radiotherapy for 30-33 daily fractions.

Registry

clinicaltrials.gov

Start Date

February 2008

End Date

August 2012

Last Updated

12 years ago

Study Type

Interventional

Study Design

Single Group