A study to compare effectiveness of Yogaraja Guggulu Rasayana and Lashuna Rasayana in Knee pain relief in Osteoarthritis of Knee.

Phase 2/3

Not yet recruiting

• Conditions: Osteoarthritis of knee, unspecified. Ayurveda Condition: JANUBEDAH (KEVALAVATA),

• Registration Number: CTRI/2025/05/087531

Brief Summary

This is a randomizedcomparative clinical study to evaluate the effectiveness of group A- YogarajaGuggulu Rasayana which will be given for 30 days in the dosage of 6 tablets ODof 450mg after Koshta Shodhana of 1 day with Eranda Taila and Shunti Kashaya. GroupB- Lashuna Rasayana for 30 days in dosage of 12 capsules of 500mg OD with milkafter 1 day of Koshta Shodhana with Eranda Taila and Shunti Kashaya. The groupB subjects after 30 days of medicine will be given 20gm of Trivrut Lehya withmilk for 1 day, morning on empty stomach for Shodhana. There will be 15subjects in each group and selection will be based on permuted blockrandomization method. The study will be conducted in Sri DharmasthalaManjunatheshwara college of Ayurveda,Hospital and Research Centre,Kuthpady,Udupi.The primary outcomes are WOMAC scale for Osteoarthritis, Pain Visual Analog Scale,range of motion and functional ability. Secondary outcome measures are gait, swelling,stiffness and tenderness. The assessment will be done on 0th day and 30th day.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2025-05-25
• Study Start: 2025-06-23

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

All participants fulfilling the diagnostic criteria from the age of 30 to 70 years Participants willing to sign the informed consent form to participate in the research.

Exclusion Criteria

Subjects suffering from illnesses like Rheumatoid Arthritis, Gouty Arthritis ,Systemic Lupus Erythematous, Fracture Any other metabolic and auto Immune joint pathologies Pregnant women and lactating women Patients unfit for Guggulu or Lashuna intake.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Assessment is done on 0th and 30th day	Assessment will be done on the basis of Subjective and Objective criteria on 0 and 30th day
4)Functional ability	Assessment will be done on the basis of Subjective and Objective criteria on 0 and 30th day
Time required to cover 30 meters in seconds	Assessment will be done on the basis of Subjective and Objective criteria on 0 and 30th day
10 sit up time required	Assessment will be done on the basis of Subjective and Objective criteria on 0 and 30th day
1)WOMAC index of Osteoarthritis	Assessment will be done on the basis of Subjective and Objective criteria on 0 and 30th day
2)Pain Visual Analog Scale	Assessment will be done on the basis of Subjective and Objective criteria on 0 and 30th day
3)Limitation of range of moments with the help of Goniometer	Assessment will be done on the basis of Subjective and Objective criteria on 0 and 30th day
time taken to climb 10 steps	Assessment will be done on the basis of Subjective and Objective criteria on 0 and 30th day

Secondary Outcome Measures

Name	Time	Method
1)Gait	2)Swelling

Trial Locations

Locations (1)

Sri Dharmasthala Manjunatheshwara College of Ayurveda, Hospital and Research Centre,Kuthpady,Udupi.; 🇮🇳 Udupi, KARNATAKA, India

Sri Dharmasthala Manjunatheshwara College of Ayurveda, Hospital and Research Centre,Kuthpady,Udupi.

🇮🇳Udupi, KARNATAKA, India

Dr Sanjana S Nadagouda

Principal investigator

9380863443

sanjananadagouda@gmail.com