The Quality of Recovery After General Anesthesia With Desflurane and Sevoflurane in Endoscopic Ureteral Lithotripsy

Not Applicable

Completed

• Conditions: Anesthesia
• Interventions: Other: Other

• Registration Number: NCT04712162
• Lead Sponsor: Gia Dinh People Hospital

Brief Summary

The good quality of recovery after general anesthesia is one of goals for short procedures and ambulatory surgeries. The study's objective was to compare the quality of recovery after general anesthesia with desflurane and sevoflurane with laryngeal mask airway for endoscopic ureteral lithotripsy.

Detailed Description

This is a randomized controlled trial. There were 60 cases of endoscopic ureteral lithotripsy under general anesthesia with laryngeal mask airway were enrolled. All cases were randomly divided into two group (desflurane or sevoflurane). Each group had 30 cases. Primary outcome was time to awakening. Secondary outcomes were time to wash-out of volatile anesthetics, time to extubation, irritation after awakening, and modified Aldrete score.

Statistical analysis was performed by using Kaplan-Meieir curve and log-rank test for time to adequate depth of anesthesia and time to awakening; t-test for time to wash-out of volatile anesthetics; chi-square test for depth of anesthesia by PRST score, irritation after awakening and Aldrete score; Fisher test for adverse effects of volatile anesthetics.

The research was approved by Gia Dinh People Hospital ethics committee

Study Timeline

• Study Start: 2019-11-19
• Primary Completion: 2020-05-07
• Study Completion: 2020-05-07
• Status Verified: 2021-01
• Study First Submitted: 2021-01-12
• Study First Submitted QC: 2021-01-13
• Last Update Submitted: 2021-01-13
• Study First Posted: 2021-01-15
• Last Update Posted: 2021-01-15

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• All eligible subjects who underwent endoscopic ureteral lithotripsy under general anesthesia
• ASA I and II

Exclusion Criteria

• Contraindication to laryngeal mask airway.
• Indication for conversion to tracheal intubation during surgery.
• History of malignant hyperthermia.
• Pregnancy.
• Obese (BMI >25 kg/m2).
• Substances abuse.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
S: maintain anesthesia with sevoflurane.	Other	S: maintain anesthesia with Sevorane® (Sevoflurane) at 2%. Volatile concentration was titrated according to end-tidal MAC to maintain 0.7-1.3 MAC using end-tidal monitor of Dräger Primus anesthesia machine.
D: maintain anesthesia with desflurane	Other	D: maintain anesthesia with Suprane® (Desflurane) at 6%. Volatile concentration was titrated according to end-tidal MAC to maintain 0.7-1.3 MAC using end-tidal monitor of Dräger Primus anesthesia machine.

Primary Outcome Measures

Name	Time	Method
Time to awakening	After stopping volatile anesthetics to patient awakening, up to 30 minutes.	Time required for awakening

Secondary Outcome Measures

Name	Time	Method
Irritation after awakening	After awakening to eligible discharge, up to 2 hours.	Aono score \>2
Time to wash-out of volatile anesthetics	After stopping volatile anesthetics to complete wash-out of volatile anesthetics, up to 30 minutes	Time required for washing out volatile anesthetics
Time to extubation	After stopping volatile anesthetics to readiness for extubation, up to 30 minutes	Time required for successful extubation.
Adverse effects of volatile anesthetics	After providing volatile anesthetics until they were stopped, up to 90 minutes	Hypotension, cough, nausea and vomitting.

Trial Locations

Locations (1)

Anesthesiology Department of Gia Dinh People Hospital; 🇻🇳 Ho Chi Minh City, Vietnam