Application of Fecal Immunochemical Test for Improving Advanced Adenoma Detection in Colorectal Cancer Screening
概览
- 阶段
- 不适用
- 干预措施
- 未指定
- 疾病 / 适应症
- Colorectal Cancer
- 发起方
- Shandong University
- 入组人数
- 5000
- 试验地点
- 2
- 主要终点
- The efficacy of fecal immunochemical test to detect advanced adenoma
- 最后更新
- 4年前
概览
简要总结
Early detecting and removing of colorectal advanced adenomas can reduce incidence of colorectal cancer. In order to reduce the incidence of colorectal cancer, improve the early diagnosis of colorectal cancer, the investigators conducted this study to explore diagnostic accuracy of fecal immunochemical test in colorectal cancer screening population.
详细描述
Colorectal cancer accounts for approximately 10% of all annually diagnosed cancers and cancer-related deaths worldwide. With progress of developing countries, it is predicted that the incidence of colorectal cancer worldwide will increase to 2.5 million new cases in 2035. The majority of colorectal cancer is thought to arise from precancerous lesions through the adenoma-carcinoma pathway. Detecting and removing of colorectal advanced adenomas can reduce incidence of colorectal cancer. In order to reduce the incidence of colorectal cancer, improve the early diagnosis of colorectal cancer, the investigators conducted this study to explore diagnostic accuracy of fecal immunochemical test in colorectal cancer screening population.
研究者
Yanqing Li
Clinical Professor
Shandong University
入排标准
入选标准
- •Adults 50-75 years old
排除标准
- •People with history of intestinal surgery;
- •People with history of colorectal cancer;
- •People with history of inflammatory bowel disease, ischemic enteritis, vascular malformation of intestine or other disease resulting in intestinal tract bleeding;
- •People with symptoms including visible rectal bleeding, hematuria, severe and acute diarrhea;
- •Pregnancy, lactation or menstrual phase;
- •Severe congestive heart failure or other sever disease cause cannot tolerate colonoscopy.
结局指标
主要结局
The efficacy of fecal immunochemical test to detect advanced adenoma
时间窗: 6 months
The detection rate and positive predictive value of fecal immunochemical test to detect advanced adenoma
次要结局
- The efficacy of fecal immunochemical test to detect colorectal cancer(6 month)
- The efficacy of fecal immunochemical test to detect colorectal neoplasms(6 month)