JPRN-jRCTs061180033已完成1 期
A phase I study of combination adjuvant immunotherapy with HSP70 derived peptide, GPC3 derived peptide, IMP321 and Hiltonol for patients with resectable hepatocellular carcinoma - A phase I study of combination adjuvant immunotherapy with HSP70 derived peptide, GPC3 derived peptide, IMP321 and Hiltonol for patients with resectable hepatocellular carcinoma
agano Hiroaki0 个研究点目标入组 20 人开始时间: 2019年3月4日最近更新:
适应症
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 发起方
- 入组人数
- 20
研究概览
简要总结
Conclusions: This novel therapeutic vaccine was safe as perioperative immunotherapy for patients with HCC and has the potential to convert immunologically cold HCC tumors into hot tumors by inducing CD8+ T cell infiltration into tumors.
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- >= 20age old 至 ot applicable（—）
- 性别
- All
入选标准
- •1. HCC proven by histology or imaging (CT or MRI)
- •2. Patients with HLA-A*2402, -A*0201, -A*0206
- •3. HCC with clinical Stage II-Iva, without cVp2, cVv2, which may be performed curative resection
- •4. Age; 20>=
- •5. Performance Status (PS); 0-1, Eastern Cooperative Oncology Group (ECOG)
- •6. Preserved organ functions (number of WBCs more than 2.0x103/mm3; % of lymphocyte >=15; number of platelets >=7.5x103/mm3; hemoglobin >=8.0 g/ dl; creatinine <=2.5 times of upper normal limit)
- •7. Patients provided written, informed consent to participate
排除标准
- •The exclusion criteria were, double cancer, pneumonitis, severe allergy, severe infection, neurological disturbance, uncontrolled general diseases, heart diseases, general steroid treatment, or any prior therapies using same agents of this study.
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