Middle Cerebral To Umbilical Artery Doppler Ratio And Amniotic Fluid Volume Measurement In Post-date Pregnancies in King Khalid Military Central City

• Conditions: Pregnancy, Prolonged
• Interventions: Other: ultrasound and Doppler examination

• Registration Number: NCT02255903
• Lead Sponsor: Benha University

Brief Summary

The aim of this study is to assess the values of MCA PI / UA PI and MCA RI / UA RI ratios and amniotic fluid volume in predicting the adverse perinatal fetal outcome in uncomplicated postdate pregnancy

Detailed Description

The Study Will be a case-control study that will be conducted at Banha University Hospital and AFHSR in Saudi Arabia after the approval of Institutional ethical committee. One hundred pregnant women will be recruited from antenatal clinic. Starting from November 2022. An informed consent will be obtained from the patients . The patients will be subdivided into two groups:

Group 1(Control Group):consist of 100 pregnant females with gestational age 37-40 weeks.

Group 2 (post date Group):consist of 100 pregnant females with gestational age 41 weeks or more.

Inclusion criteria:

1. Singleton, viable fetus in the vertex presentation.

2. History of regular menstrual cycles.

3. Gestational age calculated from the first day of last menstryal period or by first-trimester or second-trimester (before 20 weeks) ultrasound examination.

4. No obstetric or medical complications of pregnancy apart from post-date pregnancy

All patients will be subjected to:

1. Detailed history: including, personal history, menstural history, obstetric history, present history and past history.

2. Physical examination: general, abdominal and pelvic examination.

3. Investigations: including, A- Ultrasound examintion for amniotic fluid index (AFI) measurement.

B- Doppler studies:

i - Middle cerebral artery pulsatility index (MCA -PI) and resistace index(MCA-RI).

ii - Umbilical artery pulsatility index (UA-PI) and resistance index (UA-RI). iii - Cerebro-Placental ratio (CPR).

Study Timeline

• Study First Submitted: 2014-09-26
• Study First Submitted QC: 2014-09-30
• Study First Posted: 2014-10-03
• Status Verified: 2022-01
• Last Update Submitted: 2022-01-30
• Study Start: 2022-02
• Last Update Posted: 2022-02-14
• Primary Completion: 2023-05
• Study Completion: 2023-08

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 200

Inclusion Criteria

1. Singleton, viable fetus in the vertex presentation
2. History of regular menstrual cycles
3. Gestational age calculated from the first day of last menstryal period or by first-trimester or second-trimester (before 20 weeks) ultrasound examination
4. No obstetric or medical complications of pregnancy apart from post-date pregnancy

Exclusion Criteria

1. Patients unsure of their dates
2. Medical disorders with pregnancy as (hypertension, diabetes mellitus or Rh isoimmunization)
3. Prelabor rupture of membranes
4. Polyhydramnios
5. Women with multiple pregnancy
6. Congenital fetal anomalies
7. Antepartum hemorrhage
8. Previus cesarean section
9. Fetal malpresentation

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Group 2 (post date Group)	ultrasound and Doppler examination	ultrasound and Doppler examination:will be done for 100 pregnant females with gestational age 41 weeks or more
Group 1(Control Group):	ultrasound and Doppler examination	ultrasound and Doppler examination: of 100 pregnant females with gestational age 37-40 weeks.

Primary Outcome Measures

Name	Time	Method
Adverse pregnancy outcome	at time of delivery

Trial Locations

Locations (1)

AFHSR; 🇸🇦 Khamis Mushait, Afhsa, Saudi Arabia