MULTIPLE COVID-19 VACCINATION ASSOCIATED WITH ACUTE CORONARY SYNDROME: Retrospective Case-Control Study

Completed

• Conditions: acute coronary syndrome after multiple covid vaccination; covid vaccination adverse effects, viral vector vaccine, mRNA vaccine, acute coronary syndrome

• Registration Number: TCTR20240422002
• Lead Sponsor: /A

Brief Summary

umber of covid vaccination shots don't increase risk of acute coronary syndrome (p 0.22) whereas mRNA covid vaccination has higher risk of acute coronary syndrome than viral vector covid vaccination 48% (p 0.03). However after adjusting risk factor of ACS variables with multivariable logistic regression, the results are showed that only aging, male gender, smoking, hypertension, and diabetes have higher associated with acute coronary syndrome.

Detailed Description

Not available

Study Timeline

• Study Completion: 2023-06-29
• Study Start: 2024-04-22
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 154

Inclusion Criteria

1. case group : Thai patient whom age between 18-75 years old presented with ACS chest pain and received CAG at Bangkok Phuket hospital
2. control group : Thai patient whom age between 18-75 years old presented with non-ACS chest pain at Bangkok Phuket hospital which were labeled ICD-10 as coronary spasm, pulmonary embolism, pericarditis, myocarditis, aortic dissection, costochondritis, chest pain, GERD.
3. Having covid-19 vaccination history of AZD1222, BNT162b2, mRNA-1273 during 1st Jan 2022 to 31st Oct 2023 from Thai co-vaccine database.
4. PCR or ATK for covid-19 infection at the presenting day showed negative results.

Exclusion Criteria

1. History recent myocardial infarction within 6 months before hospital visiting date
2. History of cardiac arrhythmia
3. History of trauma prior of chest pain
4. Secondary myocardial infarction cause such as sepsis, amphetamine usage
5. Missing data
6. History severe covid-19 infection which had been hospitalization

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Acute coronary syndrome event 90 days adjusted odd ratio

Secondary Outcome Measures

Name	Time	Method
/A N/A N/A