Association between Organic cation transporter 1 (OCT1) gene polymorphisms and gastrointestinal intolerance to metformin among Thai diabetic patients

Not Applicable

Completed

• Conditions: Metformin is widely used oral hypoglycemic drug; however, about one- third of metformin- treated patients develop gastrointestinal (GI) side effects or metformin intolerance. High intraluminal GI concen; Metformin intolerance, OCT1 gene, Gastrointestinal side effect

• Registration Number: TCTR20200218001
• Lead Sponsor: Ratchadapiseksompotch Fund, Faculty of Medicine. Chulalongkorn university

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2020-02-14
• Study Start: 2020-02-18
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 98

Inclusion Criteria

-age more than 20 years old
-history of prescribed for metformin any dosage

Exclusion Criteria

-prgnancy
-IBS
-advanced cancer
-patients who had contraindication for metformin use
-cirrhosis CTP B,C

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
OCT1 polymorphism, rs628031 from August 2018 to February 2020 Direct DNA sequencing (Sanger sequencing)

Secondary Outcome Measures

Name	Time	Method
OCT1 polymorphism ; rs12208357, rs72552763 and rs1867 from August 2018 to February 2020 Direct DNA sequencing (Sanger sequencing)