TO ASSESS THE EFFECTIVENESS OF KETAMINE AS PREMEDICANT FOR PREVENTING FALL IN BLOOD PRESSURE AFTER SPINAL ANAESTHESIA IN PARTURIENTS POSTED FOR ELECTIVE CAESAREAN SECTION- A PROSPECTIVE RANDOMIZED DOUBLE BLIND CONTROLLED STUDY
Not Applicable
Not yet recruiting
- Conditions
- Health Condition 1: 1- ObstetricsHealth Condition 2: O00-O9A- Pregnancy, childbirth and the puerperium
- Registration Number
- CTRI/2022/08/044629
- Lead Sponsor
- JSS MEDICAL COLLEGE AND HOSPITA
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Not Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
PARTURIENTS OF ASA PHYSICAL CLASS II UNDERGOING ELECTIVE LOWER SEGMENT CAESAREAN SECTION UNDER SPINAL ANAESTHESIA.
Exclusion Criteria
1. CONTRAINDICATIONS TO REGIONAL ANAESTHESIA
2. PARTURIENTS WITH PLACENTA PREVIA, PREECLAMPSIA, CARDIOVASCULAR OR CEREBROVASCULAR DISEASE, GESTATIONAL DIABETES.
3. GESTATIONAL AGE <36 WEEKS OR > 41 WEEKS.
4. PRE- EXISTING ABNORMAL NEUROLOGICAL OR PSYCHIATRIC DISEASES.
5. HISTORY OF ALLERGY TO KETAMINE.
6. BMI >30 KG/M2.
7. PARTURIENT HEIGHT <150 CM OR > 170 CM.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method TO STUDY THE INCIDENCE OF HYPOTENSION AFTER SPINAL ANAESTHESIA IN CAESAREAN SECTION.Timepoint: THE FIRST 60 MINUTES FOLLOWING SPINAL ANAESTHESIA WILL BE CONSIDERED FOR ANAESTHESIA INDUCED HYPOTENSION.
- Secondary Outcome Measures
Name Time Method TO STUDY THE POSTOPERATIVE ANALGESIC AND SEDATIVE EFFECT OF KETAMINE, TO STUDY THE FETAL OUTCOME BY ASSESSING THE APGAR SCORETimepoint: 5 MINUTES UPTILL 24 HOURS
Related Research Topics
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What molecular mechanisms underlie ketamine's ability to prevent intraoperative hypotension in obstetric patients?
How does intravenous ketamine compare to ephedrine or phenylephrine as a premedicant for spinal anesthesia in elective cesarean sections?
Are there specific biomarkers that predict parturient response to ketamine premedication in preventing hypotension during spinal anesthesia?
What are the known adverse events associated with ketamine premedication in pregnant patients and how are they managed?
What combination therapies or alternative drugs are being explored alongside ketamine for managing hypotension in obstetric spinal anesthesia?