ACTRN12614000815662撤回未知
A prospective randomised double-blind, double-dummy, placebo-controlled crossover study on 15 healthy male participants to determine whether Glucagon-like peptide-1 (GLP-1) stimulates or suppresses pancreatic exocrine function in health.
Dr Adam Deane0 个研究点目标入组 15 人开始时间: 2014年7月31日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 撤回
- 发起方
- 入组人数
- 15
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomised controlled trial
- 主要目的
- Treatment
- 盲法
- Blinded (masking used)
入排标准
- 年龄范围
- 18 Years 至 35 Years（—）
- 性别
- Male
入选标准
- •Healthy Male volunteers between the ages of 18-35
排除标准
- •Inability to give informed consent
- •History of diabetes
- •History of pancreatitis
- •Lipase level >210 U/L
- •Amylase level > 110 U/L
- •Estimated glomerular filtration rate < 60ml/min
- •Impared liver function (ALT >55 U/L; Albumin <34g/l, ALP >110 U/L; Bilirubin >25 umol; GGT > 80 U/L)
- •Haemoglobin <135g/L
- •Body Mass Index >32kg/m2
- •Smoking > 10 cigarettes/day
- •Alcohol consumption >20g/day
- •Volunteers who have donated blood in the preceding 3 months
- •Female volunteers of child bearing age
- •Suffer from any chronic medical conditions such as (but not limited to) heart failure, ischaemic heart disease, chronic lung disease, autonomic dysfunction resulting from any cause active or previously treated malignancy, chronic infections (e.g viral hepatitis and HIV)
- •Suffered from any acute medical illnesses during the 4 week period before recruitment
- •Contraindications to any of the drugs used in this study (e.g. known hypersensitivity)
- •Gallstone(s) visualised on ultrasound at the screening visit.
研究者
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