Response Inhibition in Tourette Syndrome
- Conditions
- Tourette Syndrome
- Interventions
- Device: Repetitive TMS
- Registration Number
- NCT03628703
- Lead Sponsor
- Children's Hospital Medical Center, Cincinnati
- Brief Summary
Tics are the hallmark symptoms in Tourette Syndrome. Patients with Tourette Syndrome have difficulties controlling unwanted movements. The ability to control the motor system involves the pre-supplementary motor area (pre-SMA) in the brain. In this study, we will use Transcranial Magnetic Stimulation to modulate the pre-SMA and determine effect on the ability to stop an unwanted action in a behavior task (stop signal task).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 10
- Tourette Syndrome
- Autism spectrum disorder
- Mood disorder
- Epilepsy
- Implanted medical device (e.g. pacemaker, shunt, pumps)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Repetitive TMS Repetitive TMS Repetitive Intermittent Theta-Burst Transcranial Magnetic Stimulation
- Primary Outcome Measures
Name Time Method Stop Signal Reaction Time (SSRT) 30 minutes after Repetitive Transcranial Magnetic Stimulation (as it takes about 30 minutes to complete the modified Slater-Hammel stop signal task) SSRT measured from modified Slater-Hammel stop signal task performance. The SSRT is calculated by subtracting the average stop signal delay (msec) from the average go-trial reaction time. The SSRT is a measure of inhibitory behavior. The lower the SSRT value means a person is better at inhibitory control. The higher the SSRT value means a person is worse at inhibitory control.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Cincinnati Children's Hospital Medical Center
🇺🇸Cincinnati, Ohio, United States