Effect of administration route on the pharmacokinetics of cobalamin in elderly

Completed

• Conditions: Cobalamin deficiency or Vitamin B12 deficiency; 10047635

• Registration Number: NL-OMON36589
• Lead Sponsor: Stichting Apotheek der Haarlemse Ziekenhuizen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 10

Inclusion Criteria

- Cobalamin deficiency (cobalamin serum level less than 200 pmol/l)
- Age 65 years or over
- Capable of understanding the study information
- informed consent

Exclusion Criteria

- Concomitant use of nasally administered medication
- Chronic rhinitis
- Running nose
- Clinical relevant infection
- Hemodynamic Instability
- Short Nutritional Questionnaire Score (SNAQ) of 3 or over
- Use of cobalamin containing dietary supplements
- Severe Renal impairment i.e. MDRD less than 20 ml/min
- Ethical or medical reasons upon discretion of the investigators

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The AUC48hours of intramuscular compared with intranasal administration.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Not applicable</p><br>