Investigation of the stress burden of psoriasis patients before and under a modern biologic treatment

Recruiting

Conditions: L40.0
Psoriasis vulgaris

Registration Number: DRKS00023751

Lead Sponsor: niversitätsklinikum Essen (AöR), Klinik für Dermatologie, Venerologie und Allergologie

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 100

Inclusion Criteria

• Patients suffering from plaque psoriasis with an indication for systemic treatment (PASI > 10)
• Control persons, not suffering from a chronic disease

Exclusion Criteria

- Pregnant or breast-feeding women
- Insufficient communication skills in the German language, dementia or functional analphabetism
- Lack of capacity or will to consent to the study
- Existing contraindication to therapy with IL-17 or IL-23 inhibitors

Study & Design

Study Type: observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
• Comparison of cortisol and alpha amylase activity as assessed with salivary samples between psoriasis patients before the initiation of a biologic therapy (IL-23 or IL-17 inhibitors) and healthy controls<br><br>• Comparison of cortisol and alpha amylase activity as assessed with psoriasis patients' salivary samples before the initiation of a biologic therapy (IL-23 or IL-17 inhibitors) and after 4 weeks<br><br>• Comparison of psychological burden caused by symptoms of stress, depression and anxiety among psoriasis patients before the initiation of a biologic therapy (IL-23 or IL-17 inhibitors) with healthy controls<br><br>• Comparison of psychological burden caused by symptoms of stress, depression and anxiety among psoriasis patients before the initiation of a biologic therapy (IL-23 or IL-17 inhibitors) and after 4 weeks<br>

Secondary Outcome Measures

Name	Time	Method
- Correlation of salivary cortisol and alpha amylase with psoriasis severity (assessed with the established Psoriasis area and severity Index (PASI))<br>- Correlation of salivary cortisol and alpha amylase with self-reported psychosocial stress, as well as depressive and anxious symptoms<br>- Correlation of salivary cortisol and alpha amylase with blood serum pro-inflammatory cytokines