The LoDED study – safe & rapid chest pain management

Not Applicable

Completed

• Conditions: Chest pain; Circulatory System; Chest pain, unspecified

• Registration Number: ISRCTN86184521
• Lead Sponsor: orth Bristol NHS Trust

Brief Summary

2020 Results article in https://pubmed.ncbi.nlm.nih.gov/32371401/ results (added 21/05/2020) 2018 Protocol article in https://pubmed.ncbi.nlm.nih.gov/30282688/ (added 17/08/2022) 2020 Results article in https://pubmed.ncbi.nlm.nih.gov/33298603/ Patients' and health professionals' perceptions (added 31/08/2023)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2018-04-23
• Study Completion: 2019-04-03
• Last Update Posted: 11 September 2023

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 632

Inclusion Criteria

1. Age =18 years
2. Presenting to ED with chest pain and triggering the chest pain investigation pathway i.e. treating clinician intends to perform investigation to rule out a cardiac cause
3. Peak symptoms occurred <6 hours prior to presentation to the ED

Exclusion Criteria

1. ST-elevation myocardial infarction or ischaemic ECG (new T wave inversion > 3mm or ST depression > 1mm) as judged by the treating clinician
2. Clear non-ACS cause for chest pain found at presentation (e.g. pulmonary embolism, pneumonia, aortic dissection)
3. Initial hs-troponin result known to the treating clinician
4. Hospital admission indicated due to other medical/social reasons
5. Chest pain due to arrhythmia (new-onset atrial fibrillation, atrial flutter, sustained supraventricular tachycardia, second-degree or complete heart block, or sustained or recurrent ventricular arrhythmias)
6. Unable to provide written informed consent (lacks capacity)
7. Unwilling to provide written informed consent
8. Pain too severe to provide written informed consent
9. Follow-up will be impossible i.e. lives abroad or no fixed abode
10. Previous inclusion in the study
11. Prisoners
12. Pregnancy
13. Pre-existing renal failure requiring dialysis

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Successful early discharge, defined as discharge from hospital within four hours of arrival, without a Major Adverse Cardiac Event (MACE) occurring within 30 days of ED attendance