NL-OMON40814已完成不适用
The role of inflammation in myocardial infarction in young patients without risk factors: * the unhappy few* - A pilot study - - The Unhappy Few
niversitair Medisch Centrum Sint Radboud0 个研究点目标入组 80 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 80
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •Twenty patients aged between 18 and 50 year, who present with an acute ST-elevation myocardial infarction eligible for primary percutaneous coronary intervention. ;Family members:
- •Forty of their first degree healthy family members of the patients presenting with the acute myocardial infarction (two family members per patient).;Controls:
- •20 healthy controls aged 18 years or above. Controls will be matched with the cases for age, gender and cardiovascular risk factors.
排除标准
- •- If the index patient (suffering from the acute myocardial infarction) has one or more of the following factors present:
- •o Age below 18 years
- •o Diagnosis of vascular disease (e.g. previous myocardial infarction, CVA, etc)
- •o Use of statins, anti-inflammatory agents or thrombocyte aggregation inhibitors (these drugs modulate epigenetic changes in in vitro studies)
- •o Auto-immune diseases (e.g. rheumatoid arthritis)
- •o Coagulation disorder
- •o No living first degree family members aged 18 years or above
- •o Presence of two or more of the following risk factors:
- •§ Hypertension
- •§ Hypercholesterolemia
- •§ Diabetes mellitus
- •§ Active smoking or an active smoking history within the last 10 years;Family members:
- •- If the first degree relative (i.e. the participant) has one or more of the following factors present:
- •o Age below 18 years
- •o History of vascular disease (e.g. previous myocardial infarction, CVA, etc)
- •o Use of statins, anti-inflammatory agents or thrombocyte aggregation inhibitors (these drugs modulate epigenetic changes in in vitro studies)
- •o Signs or symptoms of a current infection (fever, chills)
- •o Auto-immune diseases (e.g. rheumatoid arthritis)
- •o Coagulation disorder
- •- If the control has one or more of the following factors present:
- •o Age below 18 years
- •o History of vascular disease (e.g. previous myocardial infarction, CVA, etc)
- •o A first degree family member with vascular disease (e.g. previous myocardial infarction, CVA, etc)
- •o Family relationship with the cases
- •o Use of statins, anti-inflammatory agents or thrombocyte aggregation inhibitors (these drugs modulate epigenetic changes in in vitro studies)
- •o Signs or symptoms of a current infection (fever, chills)
- •o Auto-immune diseases (e.g. rheumatoid arthritis)
- •o Coagulation disorder
研究者
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