NL-OMON40814
Completed
Not Applicable
The role of inflammation in myocardial infarction in young patients without risk factors: * the unhappy few* - A pilot study - - The Unhappy Few
niversitair Medisch Centrum Sint Radboud0 sites80 target enrollmentTBD
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Myocardial infarction
- Sponsor
- niversitair Medisch Centrum Sint Radboud
- Enrollment
- 80
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Twenty patients aged between 18 and 50 year, who present with an acute ST\-elevation myocardial infarction eligible for primary percutaneous coronary intervention. ;Family members:
- •Forty of their first degree healthy family members of the patients presenting with the acute myocardial infarction (two family members per patient).;Controls:
- •20 healthy controls aged 18 years or above. Controls will be matched with the cases for age, gender and cardiovascular risk factors.
Exclusion Criteria
- •\- If the index patient (suffering from the acute myocardial infarction) has one or more of the following factors present:
- •o Age below 18 years
- •o Diagnosis of vascular disease (e.g. previous myocardial infarction, CVA, etc)
- •o Use of statins, anti\-inflammatory agents or thrombocyte aggregation inhibitors (these drugs modulate epigenetic changes in in vitro studies)
- •o Auto\-immune diseases (e.g. rheumatoid arthritis)
- •o Coagulation disorder
- •o No living first degree family members aged 18 years or above
- •o Presence of two or more of the following risk factors:
- •§ Hypertension
- •§ Hypercholesterolemia
Outcomes
Primary Outcomes
Not specified
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