Effect of Different Sex Hormone Profiles for the Response to Physical Training
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 60
- 主要终点
- Muscle mass
研究概览
简要总结
The aim of the project is to elucidate the impact of diverse sex hormone profiles on the adaptability of muscle mass to physical training. Additionally, the project aims to investigate secondary effects on adipose tissue, tendons, and other physiological parameters associated with physical function.
详细描述
The human study is designed as a prospective study where 3 groups with different sex hormonal profiles are followed in parallel in 4 months and tested before, during (2 months) and after 4 months of physical training intervention. The three groups include a control group with regular menstrual bleeding and two groups who have an altered sex hormonal profile due to use of either IUD (containing the progestin levonorgestrel) or mini pills (containing the progestin desogestrel). Before and after the training period the following will be measured/collected: Body composition, Dietary intake, Physical Activity Level, Blood, Urine, Muscle Tissue, Adipose Tissue, Aerobic capacity in bike test, Strength and muscle function tests, and questionnaires about diet and physical activity.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •BMI 19-25
排除标准
- •Training more than 2 times per week
- •Pregnancy
- •Taking any medications known to affect the outcome parameters
研究组 & 干预措施
Non-hormonal contraception users
Non-hormonal contraception users
干预措施: Physical training (Behavioral)
IUD users
IUD users
干预措施: Physical training (Behavioral)
Progestin only pill users
Progestin only pill users
干预措施: Physical training (Behavioral)
结局指标
主要结局
Muscle mass
时间窗: 4 months
Muscle mass measured by DXA
Fat free mass
时间窗: 4 months
Fat free mass measured by DXA
次要结局
- Muscle fiber(4)
- Resting metabolic rate(4 months)
- Protein synthesis and degradation(4 months)
- Maximal oxygen uptake(4 months)
- Adipose tissue sex hormone receptors(4 months)
- Lipid profile(4 months)
- Muscle strength(4 months)
- Appetite regulatory markers(4 months)
研究者
Mette Hansen
Associate Professor
University of Aarhus