Effect of Different NanoScaffolds on Pulp Regeneration in Non-Vital Immature Permanent Teeth (Randomized Clinical Trial)
Trial Snapshot
- Phase
- Not Applicable
- Status
- Active, not recruiting
- Sponsor
- Tanta University
- Enrollment
- 40
- Locations
- 1
- Primary Endpoint
- apical closure assessed radiographically
Study Overview
Brief Summary
the clinical trial aims to evaluate efficency of different scaffolds in cases of regeneration
Detailed Description
The aim of this study is to evaluate the clinical and radiographic outcome of regenerative endodontic procedures in immature non-vital permanent teeth using different nanoscaffolds (Platelet-rich fibrin, Mesoporous silica nanoparticles, Hyaluronic acid nanoparticles, Pomegranate nanoparticles)
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- Single (Outcomes Assessor)
Eligibility Criteria
- Ages
- 9 Years to 18 Years (Child, Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Patients free from any systemic diseases that may interfer with the normal healing process.
- •Maxillary traumatized or cariously exposed non-vital immature anterior teeth.
- •Teeth don't need for post and core as a final restoration.
- •Radiographic evidence of an apical opening width more than 2 mm with or without periapical radiolucency.
- •Teeth without anatomical variations
Exclusion Criteria
- •Immunocompromised patients
- •Teeth with previous endodontic treatment.
- •Teeth with internal or external resorption
- •Radiographic evidence of root fracture.
- •Lack of patient and parent cooperation.
- •Presence of periodontal pocket depth more than 4 mm.
Arms & Interventions
Pomegranate ( punica granatum) Extract Nanoparticles scaffold
patients will recieve canal disinfection followed by induction of bleeding and injection of this scaffold directly before coronal sealing.
Pomegranate Extract Nanoparticles are synthesized from Punica granatum exract with potential antimicrobial and regenerative properties.
Intervention: Platelet rich fibrin (Procedure)
Hyaluronic Acid Nanoparticles scaffold (HA)
patients will recieve canal disinfection followed by induction of bleeding and injection of this scaffold directly before coronal sealing.
Hyalornic Acid nanoparticles are biodegradable with high water retention capacity promoting pulp tissue regeneration.
Intervention: Platelet rich fibrin (Procedure)
Mesoporous Silica Nanoparticles scaffold (MSN)
patients will recieve canal disinfection followed by induction of bleeding and injection of this scaffold directly before coronal sealing.
Mesoporous Silica Nanoparticles are biocompatible with high surface area that used as scaffold for enhancing the outcome.
Intervention: Platelet rich fibrin (Procedure)
Platelet Rich Fibrin (PRF only)
patients will recieve canal disinfection followed by induction of bleeding and placement of platelet rich fibrin as the only scaffold before coronal sealing.
platelet rich fibrin is obtained br removing the middle layer from a centrifuged blood sample and this is rich in platelets that play role in promoting tissue regeneration.
Intervention: Platelet rich fibrin (Procedure)
Outcomes
Primary Outcomes
apical closure assessed radiographically
Time Frame: 12 months after treatment
radiographic evaluation of apical closure as reduction or elimination of the apical opening of the root
Secondary Outcomes
No secondary outcomes reported
Investigators
Nada Ahmed Hashad
Effect of Different NanoScaffolds on Pulp Regeneration in Non-Vital Immature Permanent Teeth (Randomized Clinical Trial)
Tanta University